지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 109 - 122 (14page)
이용수
초록· 키워드
오류제보하기
The aptamer, known as a chemical antibody, has proven to be of high diagnostic and therapeutic value with the FDA’s first aptamer drug in 2004 and many aptamers under clinical validation. However, the clinical translation of aptamer for therapeutics has been delayed because of the limitation of using the target model during selection and a lack of information on several crucial factors, including their inherent physicochemical characterization and safety, and the function. Three-dimensional (3D) structure tissue provides proof of in-depth functionality due to their maturity and 3D complexity, enabling them to get information on the natural structure of the target for human treatment. The organ-on-a-chip integrates microfl uidic technology with 3D cell culture that possesses in vivo-like tissue-based models that have been engineered for validation to transform the commercial drug discovery. Thus, the organ-on-a-chip may off er a promising solution for the addressed problems, enhancing the clinical translation procedure for aptamer-based therapeutics. Motivated by the advantageous function of the aptamerbased organ-on-a-chip system, we update the current technology to generate aptamers using SELEX (Systematic Evolution of Ligands by EXponential Enrichment) and confi rm the application of aptamers to various long-term treatments. We can also accurately analyze the advantages of organ-on-a-chips and present the necessity of developing aptamer-based organon-a-chip systems. In this regard, the aptamer-based organ-on-a-chip is expected to increase the possibility of creating an aptamer as a therapeutic agent by more accurately selecting and verifying the aptamer that aff ects specifi c organ treatment.
목차
등록된 정보가 없습니다.
참고문헌 (82)
참고문헌 신청
Ellington, A. D. / 1990 / In vitro selection of RNA molecules that bind specifi c ligands / Nature 346:818~822
Robertson, D. L. / 1990 / Selection in vitro of an RNA enzyme that specifi cally cleaves single-stranded DNA / Nature 344:467~468
Tuerk, C. / 1990 / Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase / Science 249:505~510
Kim, S. H. / 2019 / Aptasensors for environmental monitoring of contaminants in water and soil / Curr. Opin. Environ. Sci. Health 10:9~21
Zhou, J. / 2017 / Aptamers as targeted therapeutics: current potential and challenges / Nat. Rev Drug Discov 16:181~202
Robertson, D. L. / 1990 / Selection in vitro of an RNA enzyme that specifi cally cleaves single-stranded DNA / Nature 344:467~468
Tuerk, C. / 1990 / Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase / Science 249:505~510
Kim, S. H. / 2019 / Aptasensors for environmental monitoring of contaminants in water and soil / Curr. Opin. Environ. Sci. Health 10:9~21
Zhou, J. / 2017 / Aptamers as targeted therapeutics: current potential and challenges / Nat. Rev Drug Discov 16:181~202
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