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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 115 - 120 (6page)
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초록· 키워드
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Background/Aims: Irritable bowel syndrome (IBS) is a common disease often considered as a functional intestinal disorder. Inflammation in IBS is a quite intriguing theory. The aim of this study was to investigate tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 expression in inflammatory bowel disease (IBD) patients, IBS patients and normal controls. Methods: IBS and IBD patients along with normal controls were recruited in the study. In all groups, 2 pinch biopsies were taken at each of 3 anatomical sites (terminal ileum, cecum, and rectum). IBS patients were also subcategorized according to the syndrome clinical manifestations. Two monoclonal antibodies (mAb), TNF-α mAb and IL-6 mAb, and one polyclonal antibody IL-1β mAb were applied for immunohistochemical analysis. Results: In IBD patients intensity of TNF-α and IL-1β were lower than in IBS patients or controls, while IL-6 was significantly increased comparing to the aforementioned groups. In IBS patients TNF-α was increased comparing to IBD patients or controls, while IL-6 and IL-1β were similar to controls. In IBS subgroups, TNF-α was lower in diarrhea predominant IBS patients and higher constipation predominant IBS patients. Differences among IBS subgroups regarding IL-6 and IL-1β were nonsignificant. Conclusions: IL-6 seems to be the most important proinflammatory cytokine in IBD patients, while TNF-α could play a more significant role in IBS pathogenesis.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Chadwick VS / 2002 / Activation of the mucosal immune system in irritable bowel syndrome / Gastroenterology 122:1778~1783
Oberndorff-Klein Woolthuis AH / 2004 / Irritable bowel syndrome in general practice : an overview / Scand J Gastroenterol Suppl (241):17~22
Drossman DA / 2002 / AGA technical review on irritable bowel syndrome / Gastroenterology 123:2108~2131
Cayley WE Jr / 2005 / Irritable bowel syndrome / BMJ 330:632
Spiller RC / 2005 / Irritable bowel syndrome / Br Med Bull 72:15~29
Oberndorff-Klein Woolthuis AH / 2004 / Irritable bowel syndrome in general practice : an overview / Scand J Gastroenterol Suppl (241):17~22
Drossman DA / 2002 / AGA technical review on irritable bowel syndrome / Gastroenterology 123:2108~2131
Cayley WE Jr / 2005 / Irritable bowel syndrome / BMJ 330:632
Spiller RC / 2005 / Irritable bowel syndrome / Br Med Bull 72:15~29
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