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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 759 - 771 (13page)
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초록· 키워드
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Background: The tumor microenvironment (TME) represents the many components occupying the space within and surrounding a tumor, including cells, signaling factors, extracellular matrix, and vasculature. Each component has the potential to assume many forms and functions which in turn contribute to the overall state of the TME, and further contribute to the progression and disposition of the tumor itself. The sum of these components can drive a tumor towards progression, keep a migratory tumor at bay, or even control chemotherapeutic response. The wide potential for interaction that the TME is an integral part of a tumor’s ecosystem, and it is imperative to include it when studying and modeling cancer in vitro. Fortunately, the development of tissue engineering and biofabrication technologies and methodologies have allowed widespread inclusion of TME-based factors into in vitro tissue-equivalent models. Methods: In this review, we compiled contemporary literature sources to provide an overview of the field of TME models, ranging from simple to complex. Results: We have identified important components of the TME, how they can be included in in vitro study, and cover examples across a range of cancer types. Conclusion: Our goal with this text is to provide a foundation for prospective research into the TME.
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참고문헌 (125)
참고문헌 신청
Balkwill FR / 2012 / The tumor microenvironment at a glance / J Cell Sci 125:5591~5596
Emon B / 2018 / Biophysics of tumor microenvironment and cancer metastasis—a mini review / Comput Struct Biotechnol J 16:279~287
Hanahan D / 2012 / Accessories to the crime : functions of cells recruited to the tumor microenvironment / Cancer Cell 21:309~322
Herrera-Perez RM / 2018 / Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition / PLoS One 13:e0194183
Puca L / 2018 / Patient derived organoids to model rare prostate cancer phenotypes / Nat Commun 9:2404
Emon B / 2018 / Biophysics of tumor microenvironment and cancer metastasis—a mini review / Comput Struct Biotechnol J 16:279~287
Hanahan D / 2012 / Accessories to the crime : functions of cells recruited to the tumor microenvironment / Cancer Cell 21:309~322
Herrera-Perez RM / 2018 / Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition / PLoS One 13:e0194183
Puca L / 2018 / Patient derived organoids to model rare prostate cancer phenotypes / Nat Commun 9:2404
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