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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 773 - 785 (13page)
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초록· 키워드
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Background: The breast cancer microenvironment contains a variety of stromal cells that are widely implicated in worse patient outcomes. While many in vitro models of the breast tumor microenvironment have been published, only a small fraction of these feature adipocytes. Adipocytes are a cell type increasingly recognized to have complex functions in breast cancer. Methods: In this review, we examine findings from recent examples of in vitro experiments modeling adipocytes within the local breast tumor microenvironment. Results: Both two-dimensional and three-dimensional models of adipocytes in the breast tumor microenvironment are covered in this review and both have uncovered interesting phenomena related to breast tumor progression. Conclusion: Certain aspects of breast cancer and associated adipocyte biology: extracellular matrix effects, cell-cell contact, and physiological mass transport can only be examined with a three-dimensional culture platform. Opportunities remain for innovative improvements to be made to in vitro models that further increase what is known about adipocytes during breast cancer progression.
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등록된 정보가 없습니다.
참고문헌 (101)
참고문헌 신청
Parmar H / 2004 / Epithelial-stromal interactions in the mouse and human mammary gland in vivo / Endocr Relat Cancer 11:437~458
Ward R / 2015 / Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment / Oncotarget 6:14687~14699
Wang YY / 2012 / Adipose tissue and breast epithelial cells : a dangerous dynamic duo in breast cancer / Cancer Lett 324:142~151
Pinilla S / 2009 / Tissue resident stem cells produce CCL5under the influence of cancer cells and thereby promote breast cancer cell invasion / Cancer Lett 284:80~85
Zwick RK / 2018 / Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation / Nat Commun 9:3592
Ward R / 2015 / Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment / Oncotarget 6:14687~14699
Wang YY / 2012 / Adipose tissue and breast epithelial cells : a dangerous dynamic duo in breast cancer / Cancer Lett 324:142~151
Pinilla S / 2009 / Tissue resident stem cells produce CCL5under the influence of cancer cells and thereby promote breast cancer cell invasion / Cancer Lett 284:80~85
Zwick RK / 2018 / Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation / Nat Commun 9:3592
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