지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Anti-tumor necrosis factors (anti-TNF) including adalimumab used to treat several immune-based diseases paradoxically have been reported to induce new-onset or exacerbation of psoriasiform skin eruptions. While, previous studies have indicated higher co-occurrence of psoriasis and inflammatory bowel disease (IBD) without regard to anti-TNF therapies. Clarifying whether anti-TNF therapies induce psoriasis in IBD patients is important to establish the appropriate treatment plan. Herein, we report a case of psoriasiform eruption in a pediatric patient with IBD treated with adalimumab. A 16-yearold girl, treated with adalimumab due to Crohn’s disease, presented with a 6-month history of multiple erythematous scaly papuloplaques on whole body. Histopathologic examination was compatible with psoriasis. Although the role of adalimumab in occurrence of psoriasiform eruption in this case is unclear, but a recent study reported the incidence of anti-TNF therapy induced psoriasis is higher than that of psoriasis irrelevant to anti-TNF therapy in pediatric patients with IBD.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Fu Y / 2018 / Association of Psoriasis With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis / JAMA Dermatol 154:1417~1423
Tillack C / 2014 / Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-gamma-expressing Th1 cells and IL-17A/IL-22-expressing Th17cells and respond to anti-IL-12/IL-23 antibody treatment / Gut 63:567~577
Tobin AM / 2005 / TNF alpha inhibitors in the treatment of psoriasis and psoriatic arthritis / BioDrugs 19:47~57
Sfikakis PP / 2005 / Psoriasis induced by anti-tumor necrosis factor therapy: a paradoxical adverse reaction / Arthritis Rheum 52:2513~2518
Conrad C / 2018 / TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis / Nat Commun 9:25
Tillack C / 2014 / Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-gamma-expressing Th1 cells and IL-17A/IL-22-expressing Th17cells and respond to anti-IL-12/IL-23 antibody treatment / Gut 63:567~577
Tobin AM / 2005 / TNF alpha inhibitors in the treatment of psoriasis and psoriatic arthritis / BioDrugs 19:47~57
Sfikakis PP / 2005 / Psoriasis induced by anti-tumor necrosis factor therapy: a paradoxical adverse reaction / Arthritis Rheum 52:2513~2518
Conrad C / 2018 / TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis / Nat Commun 9:25
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