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논문 기본 정보

자료유형
학술저널
저자정보
Tetsuya Kawano (Department of Orthopedic Surgery Akita University) Naohisa Miyakoshi (Department of Orthopedic Surgery Akita University) Yuji Kasukawa (Department of Orthopedic Surgery Akita University) Michio Hongo (Department of Orthopedic Surgery Akita University) Hiroyuki Tsuchie (Department of Orthopedic Surgery Akita University) Chie Sato (Department of Orthopedic Surgery Akita University) Masashi Fujii (Department of Orthopedic Surgery Akita University) Masazumi Suzuki (Department of Orthopedic Surgery Akita University) Manabu Akagawa (Department of Orthopedic Surgery Akita University) Yuichi Ono (Department of Orthopedic Surgery Akita University) Yusuke Yuasa (Department of Orthopedic Surgery Akita University) Itsuki Nagahata (Department of Orthopedic Surgery Akita University) Yoichi Shimada (Department of Orthopedic Surgery Akita)
저널정보
대한골다공증학회 Osteoporosis and Sarcopenia Osteoporosis and Sarcopenia Vol.3 No.4
발행연도
2017.1
수록면
185 - 191 (7page)

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Objectives: Glucocorticoid (GC) treatment inhibits activation of runt-related transcription factor 2 (Runx2), which is essential for osteoblast differentiation from stem cells. As a result, GC treatment results in bone loss, GC-induced osteoporosis (GIO), elevated fracture risk, and delayed bone healing. Bisphosphonates such as alendronate (ALN) are recommended for treating or preventing GIO, and lowintensity pulsed ultrasound (LIPUS) facilitates fracture healing and maturation of regenerated bone. Combined therapy with ALN and LIPUS may stimulate cancellous bone healing in GIO rats. Here, we examined the effect of ALN and LIPUS on cancellous bone osteotomy repair in the proximal tibia of GIO rats. Methods: Prednisolone (10 mg/kg body weight/day) was administered for 4 weeks to induce GIO in 6- month-old female Sprague-Dawley rats. Tibial osteotomy was then performed and daily subcutaneous injection of ALN (1-mg/kg body weight) was subsequently administered alone or in combination with LIPUS (20 min/day) for 2 or 4 weeks. Results: ALN significantly increased bone mineral density (BMD) at 2 and 4 weeks, and ALN þ LIPUS significantly increased BMD at 4 weeks. Bone union rates were significantly increased after 2 and 4 weeks ALN and ALN þ LIPUS treatment. Lastly, ALN and ALN þ LIPUS significantly increased the proportion of Runx2 positive cells at 4 weeks. Conclusions: ALN monotherapy and combined ALN and LUPUS treatment augmented BMD and stimulated cancellous bone repair with increased Runx2 expression at the osteotomy site in GIO rats. However, the combined treatment had no additional effect on cancellous bone healing compared to ALN monotherapy. © 2017 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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참고문헌 (30)

참고문헌 신청
Weinstein RS. / 2011 / Clinical practice. Glucocorticoid-induced bone disease / N Engl J Med 365:62~70 google schola Van Staa TP / 2000 / Use of oral corticosteroids and risk of fractures / J Bone Min Res 15:993~1000 google schola van Staa TP / 2002 / The epidemiology of corticosteroidinduced osteoporosis: a meta-analysis / Osteoporos Int 13:777~787 google schola Van Staa TP / 2003 / Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy / Arthritis Rheum 48:3224~3229 google schola Waters RV / 2000 / Systemic corticosteroids inhibit bone healing in a rabbit ulnar osteotomy model / Acta Orthop Scand 71:316~321 google schola

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