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학술저널
저자정보
이호현 (서강대학교) 김혜민 (서강대학교) 한현구 (서강대학교) 이민지 (서강대학교) 이선호 (서강대학교) 유홍근 (서강대학교) 장진호 (서강대학교) 김현철 (서강대학교)
저널정보
대한의용생체공학회 Biomedical Engineering Letters (BMEL) Biomedical Engineering Letters (BMEL) Vol.7 No.2
발행연도
2017.1
수록면
59 - 69 (11page)

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Ultrasound was developed several decades ago as a useful imaging modality, and it became the second real-time capabilities, and safety. Additionally, ultrasound has been used as a therapeutic tool with several therapeutic agents and in nanomedicine. Ultrasound imaging is often used to diagnose many types of cancers, including breast, stomach, and thyroid cancers. In addition, ultrasound-mediatedtherapy is used in cases of joint inflammation, rheumatoid arthritis, and osteoarthritis. Microbubbles,when used as ultrasound contrast agents, can act as echoenhancers and therapeutic agents, and they can play anessential role in ultrasound imaging and ultrasound-mediated therapy. Recently, various types of ultrasound contrastagents made of lipid, polymer, and protein shells have beenused. Air, nitrogen, and perfluorocarbon are usuallyincluded in the core of the microbubbles to enhanceultrasound imaging, and therapeutic drugs are conjugatedand loaded onto the surface or into the core of themicrobubbles, depending on the purpose and properties ofthe substance. Many research groups have utilizedultrasound contrast agents to enhance the imaging signal inblood vessels or tissues and to overcome the blood–brainbarrier or blood-retina barrier. These agents are also usedto help treat diseases in various regions or systems of thebody, such as the cardiovascular system, or as a cancertreatment. In addition, with the introduction of targetedmoiety and multiple functional groups, ultrasound contrastagents are expected to have a potential future in ultrasoundimaging and therapy. In this paper, we briefly review theprinciples of ultrasound and introduce the underlying theory,applications, limitations, and future perspectives ofultrasound contrast agents.

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