Prognostic Validation of the American Joint Committee on Cancer 8th Staging System in 24,014 Korean Patients with Breast Cancer

김이삭; 최희준; 류재민; 이세경; 유종한; 김석원; 남석진; 이정언

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자료유형: 학술저널

저자정보: 김이삭 (삼성서울병원) 최희준 (성균관대학교) 류재민 (성균관대학교) 이세경 (삼성서울병원) 유종한 (삼성서울병원) 김석원 (삼성서울병원) 남석진 (성균관대학교) 이정언 (삼성서울병원)

저널정보: 한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.21 No.2

발행연도: 2018.1

수록면: 173 - 181 (9page)

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Purpose: The American Joint Committee on Cancer (AJCC) recently released the breast cancer staging system, 8th edition, which included additional four biologic factors. However, there has been no external validation of the prognostic value of the new stages with different population-based databases. Methods: To validate the prognostic value of the new staging system in the Asian population, with a focus on Korean patients with breast cancer, we performed a retrospective study with data from the Korean Breast Cancer Society that included 24,014 patients with invasive ductal or lobular carcinoma who underwent surgery between January 2009 and January 2012 in Korea. The proportional differences were evaluated between the anatomic staging system (AJCC 7th edition) and the prognostic staging system (AJCC 8th edition, December 2017 published version). Comparisons of overall survival (OS) and disease-free survival (DFS) with Kaplan-Meier graphs and hazard ratios were also performed. Results: Our analysis included 24,014 patients (median age, 50 years; range, 20–91 years). Stage I, II, and III disease accounted for 47.6%, 43.5%, and 8.9%, respectively, of anatomic stages and 61.8%, 27.6%, and 10.8%, respectively, of clinical prognostic stages. A total of 6,272 cases (26.1%) were upstaged, 4,656 (19.4%) were downstaged, and 13,086 (54.5%) remained unchanged. OS and DFS decreased in the order from prognostic stages IA to IIIC but did not change among the anatomic stage groups. Conclusion: Our data suggests that the prognostic staging system provides superior prognostic value to the anatomic staging system in Korean patients with breast cancer.

참고문헌 (21)

참고문헌 신청

Siegel RL / 2016 / Cancer statistics, 2016 / CA Cancer J Clin 66:7~30

Zhou B / 2017 / The prognostic value of the 8th edition of the American Joint Committee on Cancer (AJCC) staging system in HER2-enriched subtype breast cancer, a retrospective analysis / Anticancer Res 37:4615~4621

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Giuliano AE / 2017 / Breast cancer: major changes in the American Joint Committee on Cancer eighth edition cancer staging manual / CA Cancer J Clin 67:290~303

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