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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 206 - 212 (7page)
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초록· 키워드
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Purpose: This study aimed to identify risk factors that have significant interaction with radiation exposure to the heart, and thus to determine candidates for heart-sparing radiotherapy (RT) among women with left breast cancer. Methods: We identified 4,333 patients who received adjuvant RT following breast-conserving surgery for ductal carcinoma in situ or invasive breast cancer from 1996 to 2010. Incidence rates of cardiovascular disease were compared between left-sided and right-sided RT, and stratified by age and risk factors such as body mass index (BMI), smoking, hyperlipidemia, hypertension, diabetes, administration of anthracycline, and trastuzumab. Results: In all patients, the cumulative incidence of cardiovascular disease was greater in patients treated with left-sided RT than in those treated with right-sided RT, but the difference was not significant (p=0.428). Smoking (hazard ratio [HR], 5.991; 95% confidence interval [CI], 2.109–17.022; p=0.002) and hyperlipidemia (HR, 5.567; 95% CI, 3.235–9.580; p<0.001) were the most powerful risk factors for cardiovascular disease. There was no significant factor that further increased the risk of cardiovascular disease after left breast RT compared to right breast RT. Conclusion: Although hyperlipidemia and smoking are risk factors for cardiovascular disease, they have not been proven to increase the risk of RT-related cardiovascular disease in Korean women.
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참고문헌 (26)
참고문헌 신청
박은화 / 2017 / Basic Facts of Breast Cancer in Korea in 2014: The 10-Year Overall Survival Progress / Journal of Breast Cancer 20(1):1~11
Jemal A / 2017 / Annual report to the nation on the status of cancer, 1975-2014, featuring survival / J Natl Cancer Inst 109:djx030
Clarke M / 2005 / Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials / Lancet 366:2087~2106
강진규 / 2016 / The clinical utilization of radiation therapy in Korea between 2009 and 2013 / Radiation oncology journal 34(2):88~95
김경수 / 2016 / Hypofractionated whole breast irradiation: new standard in early breast cancer after breast-conserving surgery / Radiation oncology journal 34(2):81~87
Jemal A / 2017 / Annual report to the nation on the status of cancer, 1975-2014, featuring survival / J Natl Cancer Inst 109:djx030
Clarke M / 2005 / Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials / Lancet 366:2087~2106
강진규 / 2016 / The clinical utilization of radiation therapy in Korea between 2009 and 2013 / Radiation oncology journal 34(2):88~95
김경수 / 2016 / Hypofractionated whole breast irradiation: new standard in early breast cancer after breast-conserving surgery / Radiation oncology journal 34(2):81~87
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