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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.10 No.5
- 발행연도
- 2018.1
- 수록면
- 533 - 542 (10page)
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Purpose: The tight junction protein claudin-5 (CLDN5) is critical to the control of endothelial cellular polarity and pericellular permeability. The role of CLDN5 in chronic obstructive pulmonary disease (COPD) remains unclear. The aim of this study was to investigate the association between CLDN5 levels and clinical variables in patients with COPD. Methods: In total, 30 patients with COPD and 30 healthy controls were enrolled in the study. The plasma CLDN5 level was checked in patients with stable or exacerbated COPD and in healthy controls. Results: The mean plasma CLDN5 level of patients with COPD was 0.63 ± 0.05 ng/mL and that of healthy controls was 6.9 ± 0.78 ng/mL (P = 0.001). The mean plasma CLDN5 level was 0.71 ± 0.05 ng/mL in exacerbated COPD patients and 0.63 ± 0.04 ng/mL in patients with stable COPD (P < 0.05). The plasma CLDN5 level among COPD subjects was correlated with the smoking amount (r = −0.530, P = 0.001). The plasma CLDN5 level in stable COPD patients was correlated with forced expiratory volume in one second (FEV1, %pred.) (r = −0.481, P = 0.037). Conclusions: The plasma CLDN5 level was not correlated with age. CLDN5 may be involved in the pathogenesis of COPD. Further studies having a larger sample size will be needed to clarify CLDN5 in COPD.
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참고문헌 (44)
참고문헌 신청
Schlingmann B / 2015 / Claudins: gatekeepers of lung epithelial function / Semin Cell Dev Biol 42:47~57
Soini Y / 2011 / Claudins in lung diseases / Respir Res 12:70
Coyne CB / 2003 / Role of claudin interactions in airway tight junctional permeability / Am J Physiol Lung Cell Mol Physiol 285:1166~1178
Kaarteenaho-Wiik R / 2009 / Claudin-1, -2, -3, -4, -5, and -7 in usual interstitial pneumonia and sarcoidosis / J Histochem Cytochem 57:187~195
Lappi-Blanco E / 2013 / Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis / Hum Pathol 44:895~907
Soini Y / 2011 / Claudins in lung diseases / Respir Res 12:70
Coyne CB / 2003 / Role of claudin interactions in airway tight junctional permeability / Am J Physiol Lung Cell Mol Physiol 285:1166~1178
Kaarteenaho-Wiik R / 2009 / Claudin-1, -2, -3, -4, -5, and -7 in usual interstitial pneumonia and sarcoidosis / J Histochem Cytochem 57:187~195
Lappi-Blanco E / 2013 / Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis / Hum Pathol 44:895~907
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