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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,943 - 1,948 (6page)
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초록· 키워드
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Since liver function is changed by chronic liver diseases, chronic liver disease can lead to different hemorheological alterations during the course of the progression. This study aims to compare alterations in whole blood viscosity in patients with chronic liver disease, focusing on the gender effect. Chronic liver diseases were classified into three categories by patient’s history, serologic markers, and radiologic findings: nonalcoholic fatty liver disease (NAFLD) (n = 63), chronic viral hepatitis B and C (n = 50), and liver cirrhosis (LC) (n = 35). Whole blood viscosity was measured by automated scanning capillary tube viscometer, while liver stiffness was measured by transient elastography using FibroScan®. Both systolic and diastolic whole blood viscosities were significantly lower in patients with LC than NAFLD and chronic viral hepatitis (P < 0.001) in male patients, but not in female patients. In correlation analysis, there were inverse relationships between both systolic and diastolic whole blood viscosity and liver stiffness (systolic: r = −0.25, diastolic: r = −0.22). Whole blood viscosity was significantly lower in male patients with LC than NAFLD or chronic viral hepatitis. Our data suggest that whole blood viscosity test can become a useful tool for classifying chronic liver disease and determining the prognosis for different types of chronic liver diseases.
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참고문헌 (35)
참고문헌 신청
Omoti CE / 2009 / The rheological profile of chronic liver disease patients in Nigeria / Clin Hemorheol Microcirc 42:279~284
Tamer S / 2007 / Comparison of rheological parameters in patients with post hepatitic and alcoholic cirrhosis / Clin Hemorheol Microcirc 36:247~252
Anwar MA / 2003 / Abnormal hemorheological properties in patients with compensated and decompensated hepatic cirrhosis / Clin Hemorheol Microcirc 29:95~101
Tripodi A / 2011 / The coagulopathy of chronic liver disease / N Engl J Med 365:147~156
Baskurt OK / 2003 / Blood rheology and hemodynamics / Semin Thromb Hemost 29:435~450
Tamer S / 2007 / Comparison of rheological parameters in patients with post hepatitic and alcoholic cirrhosis / Clin Hemorheol Microcirc 36:247~252
Anwar MA / 2003 / Abnormal hemorheological properties in patients with compensated and decompensated hepatic cirrhosis / Clin Hemorheol Microcirc 29:95~101
Tripodi A / 2011 / The coagulopathy of chronic liver disease / N Engl J Med 365:147~156
Baskurt OK / 2003 / Blood rheology and hemodynamics / Semin Thromb Hemost 29:435~450
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