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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 212 - 220 (9page)
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초록· 키워드
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The prognostic role of aberrant serum miRNA expression for predicting response to sorafenib treatment in advanced hepatocellular carcinoma (HCC) patients has not been well characterized. We aimed to identify specific serum miRNAs that are associated with positive radiologic responses or improved survival in sorafenib-treated HCC patients. miR-18a, miR-21, miR-139-5p, miR-221, miR-224, and miR-10b-3p, were selected for analysis. Serum samples from 24 patients with advanced stage HCC and 25 patients with liver cirrhosis (LC) were analyzed. All of the miRNAs except miR-21 were found to be upregulated in serum samples from HCC patients. None of the miRNAs assayed differed significantly in terms of expression between the responder and non-responder groups among HCC patients. However, miR-10b-3p levels were significantly higher in the subgroup of HCC patients with worse overall survival (fold change = 5.8, P = 0.008). Serum miRNA-10b-3p was upregulated in the presence of macrovascular invasion (MVI), and those with higher serum miRNA-10b-3p had significantly shorter survival during treatment (P = 0.042). Although no single serum miRNA was predictive of response to sorafenib treatment, analysis of serum miR-10b-3p levels may be valuable for diagnosis of HCC and prediction of survival of sorafenib-treated patients.
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참고문헌 (33)
참고문헌 신청
European Association For The Study Of The Liver / 2012 / European Organisation For Research And Treatment Of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma / J Hepatol 56:908~943
Shao YY / 2015 / Predictive biomarkers of sorafenib efficacy in advanced hepatocellular carcinoma: are we getting there? / World J Gastroenterol 21:10336~10347
Borel F / 2012 / Diagnostic and therapeutic potential of miRNA signatures in patients with hepatocellular carcinoma / J Hepatol 56:1371~1383
Li W / 2008 / Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma / Int J Cancer 123:1616~1622
Connolly E / 2008 / Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype / Am J Pathol 173:856~864
Shao YY / 2015 / Predictive biomarkers of sorafenib efficacy in advanced hepatocellular carcinoma: are we getting there? / World J Gastroenterol 21:10336~10347
Borel F / 2012 / Diagnostic and therapeutic potential of miRNA signatures in patients with hepatocellular carcinoma / J Hepatol 56:1371~1383
Li W / 2008 / Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma / Int J Cancer 123:1616~1622
Connolly E / 2008 / Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype / Am J Pathol 173:856~864
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