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자료유형
학술저널
저자정보
(인하대학교) (인하대학교) (인하대학교)
저널정보
대한평형의학회 Research in Vestibular Science Research in Vestibular Science Vol.15 No.4
발행연도
수록면
132 - 140 (9page)

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초록· 키워드

Objective: Growing hypotheses indicate the galvanic vestibular stimulation (GVS) as an alternative method to manage the symptoms of parkinson’s disease (PD). GVS is easy and safe for use, and non-invasive. However, it is elusive how the neural infor-mation caused by GVS is transmitted in the central nervous system and relieves PD symptoms. To answer this question, we investigated the transmission of neural infor-mation by GVS in the central vestibular system, focused on vestibular nucleus (VN).Methods: Twenty guinea pigs were used for this study for the extracellular neuronal recordings in the VN. The neuronal responses to rotation and GVS were analyzed by curve-fitting, and the numerical responding features, amplitudes and baselines, were computed. The effects of stimuli were examined by comparing these features.Results: Twenty six vestibular neurons (15 regular and 11 irregular neurons) were recorded. Comparing the difference of baselines, we found the neural information was linearly transmitted with a reduced sensitivity (0.75). The linearity in the neural tran-smission was stronger in the neuronal groups with regular (correlation coefficient [Cor. Coef.]=0.91) and low sensitive units (Cor. Coef.=0.93), compared with those with irregular (Cor. Coef.=0.86) and high-sensitive neurons (Cor. Coef.=0.77).Conclusion: The neural information by GVS was linearly transmitted no matter what the neuronal characteristics were.Res Vestib Sci 2016;15(4):132-140
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