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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 295 - 300 (6page)
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초록· 키워드
오류제보하기
Alzheimer’s disease (AD) is characterized by cognitive impairment, progressive neurodegeneration, and Ab accumulation. Ab oligomers can lead to synaptic damage via alterations in glutamate receptors and excitotoxicity, as well as mitochondrial dysfunction. AD is associated with various biological indicators, including (1) predisposing factors such as genetic risk factors, (2) laboratory markers such as Ab and tau protein, and (3) diagnostic markers such as MRI and PET findings. However, these markers are not confirmed, invasive, or expensive. In the present study, we employed nuclear magnetic resonance (NMR) methods that are inexpensive, time-efficient, and can be performed using samples obtained from various easily accessible sources such as cerebrospinal fluid, plasma, and peripheral tissue, thus highlighting the clinical utility of this approach. NMR analyses of blood metabolites showed that glutamine, glutamate, leucine, oxaloacetate, aspartate, isoleucine, and 3-hydroxyisovalerate are increased in patients with AD compared with control individuals. These metabolites seem to be related to mitochondrial dysfunction. Our data indicated that 3-hydroxyisovalerate, which is linked to known pathologic processes associated with mitochondrial dysfunction and accelerated neurodegeneration, was increased in the blood samples of patients with AD.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
American Psychiatric Association / 2000 / Diagnostic and statistical manual of mental disorders DSM-IV-TR
Antuono PG / 2001 / Decreased glutamate? glutamine in Alzheimer’s disease detected in vivo with 1H-MRS at 0.5 T / Neurology 56:737~742
Atlante A / 2001 / Glutamate neurotoxicity, oxidative stress and mitochondria / FEBS Lett 497:1~5
Beal MF / 1998 / Mitochondrial dysfunction in neurodegenerative diseases / BBA Bioenerg :211~223
Blass JP / 2001 / Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia? / J Neurosci Res 66:851~856
Antuono PG / 2001 / Decreased glutamate? glutamine in Alzheimer’s disease detected in vivo with 1H-MRS at 0.5 T / Neurology 56:737~742
Atlante A / 2001 / Glutamate neurotoxicity, oxidative stress and mitochondria / FEBS Lett 497:1~5
Beal MF / 1998 / Mitochondrial dysfunction in neurodegenerative diseases / BBA Bioenerg :211~223
Blass JP / 2001 / Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia? / J Neurosci Res 66:851~856
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