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학술저널
저자정보
김원구 (울산대학교) 김원배 (울산대학교) 우경지 (질병통제예방센터) 김혜진 (질병통제예방센터) 조유미 (질병통제예방센터) 김태용 (울산대학교) 김선욱 (성균관대학교) 신명희 (성균관대학교) 박진우 (충북대학교) 박해린 (차의과학대학교) 오경원 (질병통제예방센터) 정재훈 (성균관대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.32 No.1
발행연도
2017.1
수록면
106 - 114 (9page)

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Background: No nationwide epidemiological study evaluating the prevalence of subclinical and overt forms of hypothyroidism andhyperthyroidism has yet been conducted in Korea. This study aimed to evaluate the reference range of serum thyroid stimulatinghormone (TSH) and the national prevalence of thyroid dysfunctions in Korea. Methods: Nation-wide cross-sectional data were analyzed from a representative sample of the civilian, non-institutionalized Koreanpopulation (n=6,564) who underwent blood testing for thyroid function and anti-thyroid peroxidase antibody (TPOAb) as part of theKorea National Health and Nutrition Examination Survey VI (2013 to 2015). Results: The reference interval of serum TSH in the Korean reference population was 0.62 to 6.68 mIU/L. Based on this referenceinterval, the prevalence of overt and subclinical hypothyroidism was 0.73% (males 0.40%, females 1.10%) and 3.10% (males 2.26%,females 4.04%), respectively. The prevalence of hypothyroidism increased with age until the age group between 50 to 59 years. PositiveTPOAb were found in 7.30% of subjects (males 4.33%, females 10.62%). The prevalence of overt and subclinical hypothyroidismTPOAb-positive subjects was 5.16% and 10.88%, respectively. The prevalence of overt and subclinical hyperthyroidism was0.54% (males 0.30%, females 0.81%) and 2.98% (males 2.43%, females, 3.59%), respectively. Conclusion: The Serum TSH reference levels in the Korean population were higher than the corresponding levels in Western countries. Differences were found in the prevalence of hypothyroidism and hyperthyroidism according to age, sex, and TPOAb positivity. This study provides important baseline information for understanding patterns of thyroid dysfunction and diseases in Korea.

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