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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 33 - 43 (11page)
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초록· 키워드
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Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting 30% of the general population and 40% to 70% ofobese individuals. Adipose tissue plays a crucial role in its pathogenesis, as it produces and secretes pro- and anti-inflammatory cytokinescalled adipokines. Adiponectin and leptin have well-determined actions in terms of NAFLD pathophysiology. Adiponectin deficiencyis associated with a pro-inflammatory condition, as it is observed in obesity and other metabolic disorders. On the otherhand, increased leptin levels, above the normal levels, act as a pro-inflammatory stimulus. Regarding other adipokines (resistin, visfatin,chemerin, retinol-binding protein 4, irisin), data about their contribution to NAFLD pathogenesis and progression are inconclusive. In addition, pharmacological agents like thiazolidinediones (pioglitazone and rosiglitazone), that are used in the management ofNAFLD exert favourable effects on adipokine levels, which in turn may contribute to the improvement of liver function. This reviewsummarizes the current knowledge and developments in the association between adipokines and NAFLD and discusses possibletherapeutic implications targeting the modulation of adipokine levels as a potential tool for the treatment of NAFLD.
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참고문헌 (113)
참고문헌 신청
Fazel Y / 2016 / Epidemiology and natural history of non-alcoholic fatty liver disease / Metabolism 65:1017~1025
Reccia I / 2017 / Non-alcoholic fatty liver disease: a sign of systemic disease / Metabolism 72:94~108
Katsiki N / 2016 / Non-alcoholic fatty liver disease and dyslipidemia: an update / Metabolism 65:1109~1123
Polyzos SA / 2017 / Nonalcoholic fatty liver disease: updates on associations with the metabolic syndrome and lipid profile and effects of treatment with PPAR-${\gamma}$ agonists / Metabolism 66:64~68
Huh JH / 2017 / Obesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status / Metabolism 66:23~31
Reccia I / 2017 / Non-alcoholic fatty liver disease: a sign of systemic disease / Metabolism 72:94~108
Katsiki N / 2016 / Non-alcoholic fatty liver disease and dyslipidemia: an update / Metabolism 65:1109~1123
Polyzos SA / 2017 / Nonalcoholic fatty liver disease: updates on associations with the metabolic syndrome and lipid profile and effects of treatment with PPAR-
Huh JH / 2017 / Obesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status / Metabolism 66:23~31
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