지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 138 - 143 (6page)
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초록· 키워드
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Purpose: While perianal disease (PAD) is a characteristic of patients with Crohn disease, it has been overlooked in patients with ulcerative colitis (UC). Thus, our study aimed to analyze the incidence and the clinical features of PAD in patients with UC. Methods: We reviewed the data on 944 patients with an initial diagnosis of UC from October 2003 to October 2015. PAD was categorized as hemorrhoids, anal fissures, abscesses, and fistulae after anoscopic examination by experienced proctologists. Data on patients’ demographics, incidence and types of PAD, medications, surgical therapies, and clinical course were analyzed. Results: The median follow-up period was 58 months (range, 12–142 months). Of the 944 UC patients, the cumulative incidence rates of PAD were 8.1% and 16.0% at 5 and 10 years, respectively. The incidence rates of bleeding hemorrhoids, anal fissures, abscesses, and fistulae at 10 years were 6.7%, 5.3%, 2.6%, and 3.4%, respectively. The cumulative incidence rates of perianal sepsis (abscess or fistula) were 2.2% and 4.5% at 5 and 10 years, respectively. In the multivariate analyses, male sex (risk ratio [RR], 4.6; 95% confidence interval [CI], 1.7–12.5) and extensive disease (RR, 4.2; 95% CI, 1.6–10.9) were significantly associated with the development of perianal sepsis. Conclusion: Although the clinical course of PAD in patients with UC is not serious, in clinical practice, PAD is not rare in such patients. Therefore, careful examination and appropriate management for PAD is needed if the quality of life for patients with UC is to be improved.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Schwartz DA / 2002 / The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota / Gastroenterology 122:875~880
Fichera A / 2007 / Surgical treatment of Crohn's disease / J Gastrointest Surg 11:791~803
Tozer PJ / 2009 / Etiology of perianal Crohn's disease: role of genetic, microbiological, and immunological factors / Inflamm Bowel Dis 15:1591~1598
Eglinton TW / 2012 / The spectrum of perianal Crohn's disease in a population-based cohort / Dis Colon Rectum 55:773~777
Beaugerie L / 2006 / Predictors of Crohn's disease / Gastroenterology 130:650~656
Fichera A / 2007 / Surgical treatment of Crohn's disease / J Gastrointest Surg 11:791~803
Tozer PJ / 2009 / Etiology of perianal Crohn's disease: role of genetic, microbiological, and immunological factors / Inflamm Bowel Dis 15:1591~1598
Eglinton TW / 2012 / The spectrum of perianal Crohn's disease in a population-based cohort / Dis Colon Rectum 55:773~777
Beaugerie L / 2006 / Predictors of Crohn's disease / Gastroenterology 130:650~656
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