지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 42 - 47 (6page)
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Purpose: To identify incidence and risk factors of recurrence after discontinuation of successful antimuscarinic therapy in patients with overactive bladder (OAB). Materials and Methods: This was a prospective, multicenter trial. Patients who had antimuscarinic agents for more than 12 weeks and showed successful response were enrolled. Successful response was defined as answering 'benefit' for patient perception of treatment benefit and answer lesser than 3 points in patient's perception of bladder condition (PPBC). The enrolled patients discontinued the antimuscarinics, and we evaluated their recurrence with PPBC and OAB symptom score (OABSS) at 1, 3, 6, and 12 months. Primary purpose was to identify the recurrence rate and secondary purpose was to reveal risk factors. Results: Four hundred forty-one patients enrolled and 371 patients completed 6-month follow-up. The enrolled patients showed 1.6 points in PPBC, 2.9 points in OABSS and 1.4 points in IPSS (quality of life) which represented successful response after using antimuscarinics. The cumulative rates of recurrence were 25.6%, 42.3%, and 52.2% at 1, 3, 6 months, respectively. Among 177 patients who did not show recurrence at 6 months, 41 patients were followed up and 4 patients of the 41 patients (9.7%) showed recurrence at 12 months. On univariate and multivariate analyses of recurrence, OAB wet was the risk factor for recurrence after 6 months of discontinuation. Conclusions: Discontinuation of antimuscarinic therapy after successful treatment resulted in high recurrence rate with time and OAB wet was the independent risk factor for recurrence.
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참고문헌 (29)
참고문헌 신청
Abrams P / 2009 / Reviewing the ICS 2002 terminology report: the ongoing debate / Neurourol Urodyn 28:287
Wein AJ / 2003 / Diagnosis and treatment of the overactive bladder. / Urology 62(5 Suppl 2):20~27
Kreder K / 2002 / Long-term safety, tolerability and efficacy of extended-release tolterodine in the treatment of overactive bladder / Eur Urol 41:588~595
Chapple CR / 2004 / Randomized, double-blind placebo- and tolterodine-controlled trial of the once-daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladder / BJU Int 93:303~310
Choo MS / 2005 / Changes in overactive bladder symptoms after discontinuation of successful 3-month treatment with an antimuscarinic agent:a prospective trial / J Urol 174:201~204
Wein AJ / 2003 / Diagnosis and treatment of the overactive bladder. / Urology 62(5 Suppl 2):20~27
Kreder K / 2002 / Long-term safety, tolerability and efficacy of extended-release tolterodine in the treatment of overactive bladder / Eur Urol 41:588~595
Chapple CR / 2004 / Randomized, double-blind placebo- and tolterodine-controlled trial of the once-daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladder / BJU Int 93:303~310
Choo MS / 2005 / Changes in overactive bladder symptoms after discontinuation of successful 3-month treatment with an antimuscarinic agent:a prospective trial / J Urol 174:201~204
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