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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한비만학회 Journal of Obesity & Metabolic Syndrome Journal of Obesity & Metabolic Syndrome Vol.27 No.2
- 발행연도
- 2018.1
- 수록면
- 102 - 109 (8page)
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초록· 키워드
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Background: Uncoupling protein 1 (UCP1) plays an important role in increasing energy expenditure; thus, it is being considered as a new target for preventing obesity and metabolic complications. In this study, we investigated the effect of quercetin, a naturally occurring flavonoid, on UCP1 expression in white/brown adipose tissues (WAT/BAT). Methods: Mice were fed a high-fat diet (HFD) supplemented with or without dietary quercetin for 9 weeks, and 3T3-L1 adipocytes were treated with quercetin. Expression of UCP1 and other thermogenic genes/proteins was measured by real-time polymerase chain reaction and/or Western blotting. Results: Dietary quercetin supplementation increased the level of UCP1 in both WAT and/or BAT of HFD-fed obese mice, which was accompanied by upregulated mRNA levels of thermogenesis-related genes. Quercetin supplementation enhanced the plasma norepinephrine level and tended to upregulate β-adrenergic receptor mRNA level in the WAT of HFD-fed obese mice, accompanied by AMP-activated protein kinase (AMPK) activation. Moreover, quercetin enhanced UCP1 expression in 3T3-L1 adipocytes, and this was blunted by treatment with a peroxisome proliferator-activated receptor gamma (PPARγ) antagonist. Conclusion: These findings suggest that quercetin upregulates UCP1, implying increased WAT browning and BAT activity, via activation of the AMPK/PPARγ pathway through sympathetic stimulation. Quercetin may be useful for preventing obesity and metabolic complications.
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참고문헌 (25)
참고문헌 신청
Hotamisligil GS / 2006 / Inflammation and metabolic disorders / Nature 444:860~867
Shoelson SE / 2006 / Inflammation and insulin resistance / J Clin Invest 116:1793~1801
Peschechera A / 2013 / "Browning" of adipose tissue: regulation and therapeutic perspectives / Arch Physiol Biochem 119:151~160
Lidell ME / 2014 / Brown adipose tissue and its therapeutic potential / J Intern Med 276:364~377
Hill JO / 2012 / Energy balance and obesity / Circulation 126:126~132
Shoelson SE / 2006 / Inflammation and insulin resistance / J Clin Invest 116:1793~1801
Peschechera A / 2013 / "Browning" of adipose tissue: regulation and therapeutic perspectives / Arch Physiol Biochem 119:151~160
Lidell ME / 2014 / Brown adipose tissue and its therapeutic potential / J Intern Med 276:364~377
Hill JO / 2012 / Energy balance and obesity / Circulation 126:126~132
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Autophagy Inhibition Promotes Quercetin Induced Apoptosis in MG-63 Human Osteosarcoma cells
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AMP-activated protein kinase activation in skeletal muscle modulates exercise-induced uncoupled protein 1 expression in brown adipocyte in mouse model
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HepG2 cell에서 quercetin의 HO-1 발현을 통한 mitochondria의 생합성 유도 효과에 관한 연구
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Effect of Electroacupuncture Stimulation on Brown Adipose Tissue Thermogenesis
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Brown Adipose Tissue: Activation and Metabolism in Humans
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Quercetin reduces the injury-induced reduction of γ-enolase expression in a middle cerebral artery occlusion animal model
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Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
Diabetes and Metabolism Journal
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Quercetin attenuates neuronal cells damage in a middle cerebral artery occlusion animal model and HT-22 cells
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