지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 257 - 265 (9page)
이용수
초록· 키워드
오류제보하기
Background: Previous studies have shown that aldosterone antagonists have a proteinuria-lowering effect in patients with proteinuria and progressive proteinuric disease not adequately controlled by the use of angiotensin receptor blockers (ARBs). Aldosterone antagonists, in combination with ARBs, might improve proteinuria in patients with glomerulonephritis (GN). Methods: In the present retrospective study, we evaluated the proteinuria-lowering effect and drug safety of low-dose spironolactone (12.5 mg/day) in 42 patients with GN being treated with an ARB. Results: Proteinuria decreased from a mean total-protein-to-creatinine (TP/Cr) ratio of 592.3 ± 42.0 mg/g at baseline to 335.6 ± 43.3 mg/g after three months of treatment with spironolactone (P < 0.001). After the initial three months, the mean TP/Cr ratio increased progressively at six, nine, and 12 months; however, it was still less than the baseline value (P = 0.001, < 0.001, and < 0.001, respectively). Although serum Cr levels increased significantly at three and nine months compared with baseline (P = 0.036 and 0.026, respectively), there was no time effect of treatment (P = 0.071). Serum potassium levels tended to increase with time (P = 0.118), whereas systolic and diastolic blood pressures decreased with time (P = 0.122 and 0.044, respectively). Conclusion: Low-dose spironolactone in combination with an ARB reduced proteinuria in patients with GN, which could represent a novel treatment option in individuals whose proteinuria is not optimally controlled by the use of ARBs alone.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Remuzzi G / 2006 / Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes / J Clin Invest 116:288~296
Kidney Disease: Improving Global Outcomes / 2012 / KDIGO clinical practice guideline for glomerulonephritis / Kidney Int Suppl 2:139~274
Rocha R / 1998 / Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats / Hypertension 31:451~458
Rocha R / 1999 / Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats / Hypertension 33:232~237
Qin D / 2013 / Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis / J Nephrol 26:199~206
Kidney Disease: Improving Global Outcomes / 2012 / KDIGO clinical practice guideline for glomerulonephritis / Kidney Int Suppl 2:139~274
Rocha R / 1998 / Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats / Hypertension 31:451~458
Rocha R / 1999 / Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats / Hypertension 33:232~237
Qin D / 2013 / Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis / J Nephrol 26:199~206
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
직결장암 환자에서 Bevacizumab에 의한 단백뇨 발현과 치료효과와의 상관관계 분석
한국임상약학회지
2020 .01
-
A Case of Orthostatic Proteinuria Progressed to Persistent Proteinuria Associated with Renal Pathology
Childhood Kidney Diseases
2017 .01
-
Clinical Approach to Children with Proteinuria
Childhood Kidney Diseases
2017 .01
-
Spironolactone Attenuates Methylglyoxal-induced Cellular Dysfunction in MC3T3-E1 Osteoblastic Cells
Journal of Korean Medical Science
2021 .10
-
Impact of Angiotensin Receptor Blockers, Beta Blockers, Calcium Channel Blockers and Thiazide Diuretics on Survival of Ovarian Cancer Patients
Cancer Research and Treatment
2020 .01
-
To treat or not to treat: CUBN-associated persistent proteinuria
Kidney Research and Clinical Practice
2024 .09
-
Impact of preoperative proteinuria on renal functional outcomes after open partial nephrectomy in patients with a solitary kidney
Investigative and Clinical Urology
2017 .01
-
Hypertension, renin-angiotensin-aldosterone-system-blocking agents, and COVID-19
Clinical Hypertension
2021 .07
-
Effects of discontinuing angiotensin receptor blockers on perioperative hypotension in patients undergoing laparoscopic cholecystectomy
Medical Biological Science and Engineering
2019 .01
-
Is massive proteinuria associated with maternal and fetal morbidities in preeclampsia?
Obstetrics & Gynecology Science
2017 .01
-
Association Between Angiotensin II Receptor Blockers and the Risk of Lung Cancer Among Patients With Hypertension From the Korean National Health Insurance Service-National Health Screening Cohort
예방의학회지
2020 .01
-
Incidence and Pattern of Aminotransferase Elevation During Anti-Hypertensive Therapy With Angiotensin-II Receptor Blockers
Journal of Korean Medical Science
2022 .08
-
무증상성 단백뇨에 대한 단기 한약 투약 경과 : 증례보고
대한한방내과학회지
2018 .01
-
Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis
Kidney Research and Clinical Practice
2023 .01
-
Developing a multi-center clinical data mart of ACEI and ARB for real-world evidence (RWE)
Clinical Hypertension
2019 .01
-
Impact of Angiotensin Converting Enzyme Inhibitor versus Angiotensin Receptor Blocker on Incidence of New-Onset Diabetes Mellitus in Asians
Yonsei Medical Journal
2016 .01
-
오가피(五加皮) 수피(樹皮)와 근피(根皮)의 MIA 유도 골관절염 흰쥐에 미치는 영향 비교
대한본초학회지(본초분과학회지)
2018 .01
-
통풍을 동반한 고혈압 환자에서 요산감소를 위한 losartan과 다른 ARBs간의 임상적 의미 평가
약학회지
2016 .01
-
The Natural Course of Biopsy-Proven Isolated Microscopic Hematuria: A Single Center Experience of 350 Patients
Journal of Korean Medical Science
2016 .01
-
Hypertension in Chronic Glomerulonephritis
Electrolytes & Blood Pressure
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0