지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 170 - 174 (5page)
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초록· 키워드
오류제보하기
Objective: Progesterone is used to prevent recurrent preterm delivery, however the molecular mechanisms of its effect are incompletely understood. The objective of this study was to determine the effect of progesterone on tumor necrosis factor (TNF)-α-induced matrix metalloproteinase (MMP)-9 activity in human choriodecidual (CD) membranes. Methods: We collected CD membranes from women with uncomplicated term pregnancies who were scheduled for elective cesarean delivery (n=10). CD membranes (1×1 cm) were incubated in tissue culture media at 37°C. We pre-treated the CD membranes with progesterone (P4), 17α- hydroxyprogesterone caproate (17P), promegestone (R5020), or vehicle (ethanol) for 24 hours. The CD membranes were subsequently treated with TNF-α (with continued progesterone treatment) for 48 hours, then media was harvested for measuring MMP-9 activity by zymography and total protein was isolated from CD membrane tissues for MMP-9 expression by western blot analysis. Results: P4, 17P, and R5020 significantly reduced TNF-α-induced MMP-9 activity in fetal membrane tissue samples (P=0.0078, P=0.0156, and P=0.0391, respectively) by zymography. Western blot analysis also showed decreased expression of MMP-9 in progesterone pretreated groups (P=0.0313). Conclusion: Progesterone reduces TNF-α-induced MMP-9 activity in human CD membranes. These findings may provide further support for the role of progesterone in preventing preterm birth.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Beck S / 2010 / The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity / Bull World Health Organ 88:31~38
Martin JA / 2010 / Births: final data for 2007 / Natl Vital Stat Rep 58:1~85
Maymon E / 1999 / The tumor necrosis factor alpha and its soluble receptor profile in term and preterm parturition / Am J Obstet Gynecol 181(5):1142~1148
Fortunato SJ / 2002 / Role of tumor necrosis factor-alpha in the premature rupture of membranes and preterm labor pathways / Am J Obstet Gynecol 187:1159~1162
Mackenzie AP / 2004 / Mechanisms of abruption-induced premature rupture of the fetal membranes: Thrombin enhanced decidual matrix metalloproteinase-3 (stromelysin-1) expression / Am J Obstet Gynecol 191:1996~2001
Martin JA / 2010 / Births: final data for 2007 / Natl Vital Stat Rep 58:1~85
Maymon E / 1999 / The tumor necrosis factor alpha and its soluble receptor profile in term and preterm parturition / Am J Obstet Gynecol 181(5):1142~1148
Fortunato SJ / 2002 / Role of tumor necrosis factor-alpha in the premature rupture of membranes and preterm labor pathways / Am J Obstet Gynecol 187:1159~1162
Mackenzie AP / 2004 / Mechanisms of abruption-induced premature rupture of the fetal membranes: Thrombin enhanced decidual matrix metalloproteinase-3 (stromelysin-1) expression / Am J Obstet Gynecol 191:1996~2001
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