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학술저널
저자정보
김슬기 (가톨릭대학교 의과대학 소아과학교실) 김민채 (가톨릭대학교) 한승범 (가톨릭대학교(성의교정) 백신바이오연구소) 김성구 ((학) 가톨릭대학교서울성모병원) 이재욱 (가톨릭대학교) 정낙균 (가톨릭대학교) 조빈 (가톨릭대학교) 정대철 (가톨릭대학교) 강진한 (가톨릭대학교) 김학기 (가톨릭대학교)
저널정보
대한혈액학회 Blood Research Blood Research Vol.51 No.4
발행연도
2016.1
수록면
249 - 255 (7page)

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BackgroundAlthough intravenous acyclovir therapy is recommended for varicella zoster virus (VZV) infection in immunocompromised children, the clinical characteristics and outcomes of VZV infection in the acyclovir era have rarely been reported.MethodsThe medical records of children diagnosed with varicella or herpes zoster virus, who had underlying hematologic malignancies, were retrospectively reviewed, and the clinical characteristics and outcomes of VZV infection were evaluated.ResultsSeventy-six episodes of VZV infection (herpes zoster in 57 and varicella in 19) were identi-fied in 73 children. The median age of children with VZV infection was 11 years (range, 1‒17), and 35 (46.1%) episodes occurred in boys. Acute lymphoblastic leukemia was the most common underlying malignancy (57.9%), and 90.8% of the episodes occurred dur-ing complete remission of the underlying malignancy. Acyclovir was administered for a median of 10 days (range, 4‒97). Severe VZV infection occurred in 16 (21.1%) episodes. Although the finding was not statistically significant, a previous history of hematopoietic cell transplantation (HCT) appeared to be associated with the development of more severe episodes of herpes zoster (P=0.075).ConclusionClinical characteristics of VZV infection in immunocompromised children were not sig-nificantly different from those without it, and clinical outcomes improved after the in-troduction of acyclovir therapy. However, risk factors for severe VZV infection require further investigation in a larger population and a prospective setting.

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