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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 200 - 206 (7page)
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이 논문의 연구 히스토리 (2)
2017
Prognostic factor analysis of marginal zone lymphoma patients who were treated with R-CVP chemotherapy : R-CVP로 치료 받은 변연부 림프종 환자의 예후인자 분석
서정국
의학과
2017.01
학위논문
Platelet to lymphocyte ratio (PLR) retains independent prognostic significance in advanced stage marginal zone lymphoma patients treated with rituximab, cyclophosphamide, vincristine, and prednisone combination chemotherapy (R-CVP): Consortium for Improving Survival of Lymphoma trial
서정국
,
김원석
,
김진석
외 16명
Blood Research
2017.01
학술저널
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Background: Rituximab plus cyclophosphamide, vincristine, and prednisone (R-CVP) is one of the ef-fective chemotherapeutic regimens for patients with advanced stage marginal zone lym-phoma (MZL). However, prognostic factors that affect the outcome of treatment for MZL are not well understood. Methods: Between August 2006 and June 2013, patients with newly diagnosed stage III and IV MZL treated with R-CVP as a first-line therapy from 15 institutions were retrospectively analyzed. Patients’ clinical and laboratory data at diagnosis were collected by review of medical records. Results: A total of 80 patients were analyzed. Bone marrow involvement was observed in 30% cases. Twelve patients (15%) had nodal MZL, and 41.3% patients exhibited multiple mu-cosa-associated lymphoma tissue sites. Overall response rate was 91.3%, including 73.8% achieving complete response. Advanced MZL patients treated with R-CVP showed a 3-year progression-free survival (PFS) rate of 69.6%. Prognostic markers significantly affecting PFS in univariate analysis were platelet to lymphocyte ratio (PLR, ＜95 vs. ≥95, P=0.014), serum albumin (≤3.9 vs. ＞3.9 g/dL, P=0.008), and the International Prognostic Index (IPI) score (1 vs. 2‒4, P=0.032). In multivariate analysis, only PLR (＜95 vs. ≥95, HR 0.367, 95% CI, 0.139‒0.971, P=0.043) was an independent risk factor for PFS. Conclusion: PLR ≥95 at diagnosis is an independent prognostic marker for PFS in advanced stage MZL patients treated with R-CVP. This marker may aid clinicians in predicting the response to R-CVP chemotherapy in stage III and IV MZL patients.
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참고문헌 (39)
참고문헌 신청
Oh SY / 2007 / Nongastric marginal zone B-cell lymphoma : analysis of 247 cases / Am J Hematol 82:446~452
김진만 / 2011 / WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study / Journal of Pathology and Translational Medicine 45(3):254~260
Conconi A / 2003 / Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type / Blood 102:2741~2745
Oh SY / 2010 / Stage IV marginal zone B-cell lymphoma--prognostic factors and the role of rituximab : Consortium for Improving Survival of Lymphoma(CISL)study / Cancer Sci 101:2443~2447
Zucca E / 2013 / Addition of rituximab to chlorambucil produces superior event-free survival in the treatment of patients with extranodal marginal-zone B-cell lymphoma : 5-year analysis of the IELSG-19 Randomized Study / J Clin Oncol 31:565~572
김진만 / 2011 / WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study / Journal of Pathology and Translational Medicine 45(3):254~260
Conconi A / 2003 / Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type / Blood 102:2741~2745
Oh SY / 2010 / Stage IV marginal zone B-cell lymphoma--prognostic factors and the role of rituximab : Consortium for Improving Survival of Lymphoma(CISL)study / Cancer Sci 101:2443~2447
Zucca E / 2013 / Addition of rituximab to chlorambucil produces superior event-free survival in the treatment of patients with extranodal marginal-zone B-cell lymphoma : 5-year analysis of the IELSG-19 Randomized Study / J Clin Oncol 31:565~572
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