지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Purpose: Glufosinate-containing herbicides intoxication causes mild to severe complication, depending on patients’ factors. However, it is not clearly known whether there are factors affecting glufosinate-containing herbicides intoxicated patients who develop complications. Thus, we sought to identify independent factors comparing the complicated group with the non-complicated group and to predict which patients will develop subsequent medical complication. Methods: The medical records of patients with exposure to Glufosinate-containing herbicides at a tertiary academic university hospital in Korea from January 2012 to April 2015 were reviewed retrospectively. Demographic and clinical data of 75 patients were then analyzed by univariate and multivariate stepwise logistic regression analyses to identify potential predictors of significant complications following acute Glufosinate-containing herbicides poisoning for comparison of complicated patients with non-complicated patients. Results: Of 75 patients, 44 (58.6%) had medical complications and 6 (8%) were dead. Neurologic complications (n=26, 35%) were the most common including seizure (n=18), delirium tremens (n=5), and amnesia (n=4). The results of univariate analysis showed that an advanced age (>60 years old), higher ingested amount of the herbicide (>100 mL), vomiting at arrival, medical history of hypertension, metabolic acidosis, and systemic inflammatory response score (SIRS)≥2 were significant factors. However, the results of multivariate analysis showed that an advanced age (p<0.001) and higher ingested amount of herbicide (p<0.001) were independent factors associated with serious complications and require aggressive medical treatment. Conclusion: The results of this study showed that age>60 years, and amount ingested>100 mL were significant predictive factors for significant medical complications in patients with Glufosinate-containing herbicides poisoning.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bayer E / 1972 / Stoffwechselprodukte von Mikroorganismen. 98. Mitteilung. Phosphinothricin und PhosphinothricylAlanyl-Alanin / Helvetica Chimica Acta 55:224~239
Omura S / 1984 / The structure of phosalacine, a new herbicidal antibiotic containing phosphinothricin / J Antibiot(Tokyo) 37:939~940
Omura S / 1984 / Phosalacine, a new herbicidal antibiotic containing phosphinothricin. Fermentation, isolation, biological activity and mechanism of action / J Antibiot(Tokyo) 37:829~835
Hoerlein G / 1994 / Glufosinate (phosphinothricin), a natural amino acid with unexpected herbicidal properties / Rev Environ Contam Toxicol 138:73~145
Ebert E / 1990 / Summary of safety evaluation toxicity studies of glufosinate ammonium / Food Chem Toxicol 28:339~349
Omura S / 1984 / The structure of phosalacine, a new herbicidal antibiotic containing phosphinothricin / J Antibiot(Tokyo) 37:939~940
Omura S / 1984 / Phosalacine, a new herbicidal antibiotic containing phosphinothricin. Fermentation, isolation, biological activity and mechanism of action / J Antibiot(Tokyo) 37:829~835
Hoerlein G / 1994 / Glufosinate (phosphinothricin), a natural amino acid with unexpected herbicidal properties / Rev Environ Contam Toxicol 138:73~145
Ebert E / 1990 / Summary of safety evaluation toxicity studies of glufosinate ammonium / Food Chem Toxicol 28:339~349
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