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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose: To investigate the change in mitogen-activated protein kinase pathways in the brain tissue after therapeutic hypothermia in the swine cardiac arrest model. Methods: After the return of spontaneous circulation by cardiopulmonary resuscitation, following a 6 min of no-flow time induced by ventricular fibrillation, pigs (n=24) were randomly assigned to one of four groups (sham, normothermia, 24 hr of therapeutic hypothermia, 48 hr of therapeutic hypothermia). After 24 or 48 hr of therapeutic hypothermia (core temperature 32-34C), the pigs were then rewarmed to 36℃ for a period of 8 hr. At 60 hr upon the return of spontaneous circulation, the pigs were sacrificed and brain tissues were harvested. Results: We measured the tissue levels of p38, JNK, and ERK pathway expressions from the hippocampus of the swine brain in all four groups. The phosphorylated p38-to-p38 ratio and phosphorylated JNK-to-JNK ratio were significantly increased in all of the intervention groups compared with the sham group. The phosphorylated ERK-to-ERK ratio was increased only in the therapeutic hypothermia groups (p-value=0.026 in the 24 hr of therapeutic hypothermia group and p-value=0.002 in the 48 hr of therapeutic hypothermia group, compared with the sham group). Conclusion: The p38 and JNK pathways were also activated during therapeutic hypothermia and normothermia. However, the ERK pathway was activated only in therapeutic hypothermia. Therapeutic hypothermia activated the ERK pathway in ischemia-reperfusion injury of the brain tissue after cardiac arrest, which seemed to be dependent on the duration of therapeutic hypothermia.
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참고문헌 (38)
참고문헌 신청
Writing Group Members / 2010 / Heart disease and stroke statistics - 2010 update: a report from the American Heart Association / Circulation 121:e46~e215
Nichol G / 2008 / Regional variation in out-of-hospital cardiac arrest incidence and outcome / JAMA 300:1423~1431
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Laurent I / 2002 / Reversible myocardial dysfunction in survivors of out-of-hospital cardiac arrest / J Am Coll Cardiol 40:2110~2116
Sunde K / 2007 / Implementation of a standardised treatment protocol for post resuscitation care after out-of-hospital cardiac arrest / Resuscitation 73:29~39
Nichol G / 2008 / Regional variation in out-of-hospital cardiac arrest incidence and outcome / JAMA 300:1423~1431
Rea TD / 2004 / Incidence of EMS-treated out-of-hospital cardiac arrest in the United States / Resuscitation 63:17~24
Laurent I / 2002 / Reversible myocardial dysfunction in survivors of out-of-hospital cardiac arrest / J Am Coll Cardiol 40:2110~2116
Sunde K / 2007 / Implementation of a standardised treatment protocol for post resuscitation care after out-of-hospital cardiac arrest / Resuscitation 73:29~39
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