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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 71 - 74 (4page)
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Study Design: Histopathological analyses were performed in ligamentum flavum (LF) hypertrophy patients with lumbar spinal stenosis (LSS) and lumbar disc herniation (LDH). Purpose: The aim of the present study was to evaluate histopathological changes in LF patients with LSS and LDH. Overview of Literature: LSS is the most common spinal disorder in elderly patients. This condition causes lower back and leg pain and paresis, and occurs as a result of degenerative changes in the lumbar spine, including bulging of the intervertebral discs, bony proliferation of the facet joints, and LF thickening; among these, LF thickening is considered a major contributor to the development of LSS. Methods: A total of 71 patients operated with the surgical indications of LSS and LDH were included. LF samples were obtained from 31 patients who underwent decompressive laminectomy for symptomatic degenerative LSS (stenotic group) and from 40 patients who underwent lumbar discectomy for LDH (discectomy group). LF materials were examined histopathologically, and other specimens were examined for collagen content, elastic fiber number and array, and presence of calcification. Results: The stenotic and discectomy groups did not differ with regard to mean collagen concentration or mean elastic fiber number (p =0.430 and p =0.457, respectively). Mean elastic fiber alignment was 2.36±0.99 in the stenotic group and 1.38±0.54 in the discectomy group (p <0.001). Mean calcification was 0.39±0.50 in the stenotic group, whereas calcification was not detected (0.00±0.00) in the discectomy group; a statistically significant difference was detected (p <0.001) between groups. Conclusions: LF hypertrophy in spinal stenosis may occur as a result of elastic fiber misalignment along with the development of calcification over time. Further studies determining the pathogenesis of LSS are needed.
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참고문헌 (10)
참고문헌 신청
Nakatani T / 2002 / Mechanical stretching force promotes collagen synthesis by cultured cells from human ligamentum flavum via transforming growth factorbeta1 / J Orthop Res 20:1380~1386
Hansson T / 2009 / The narrowing of the lumbar spinal canal during loaded MRI: the effects of the disc and ligamentum flavum / Eur Spine J 18:679~686
Yoshida M / 1992 / Hypertrophied ligamentum flavum in lumbar spinal canal stenosis: pathogenesis and morphologic and immunohistochemical observation / Spine (Phila Pa 1976) 17:1353~1360
Kosaka H / 2007 / Pathomechanism of loss of elasticity and hypertrophy of lumbar ligamentum flavum in elderly patients with lumbar spinal canal stenosis / Spine (Phila Pa 1976) 32:2805~2811
Zhong ZM / 2011 / Hypertrophy of ligamentum flavum in lumbar spine stenosis associated with the increased expression of connective tissue growth factor / J Orthop Res 29:1592~1597
Hansson T / 2009 / The narrowing of the lumbar spinal canal during loaded MRI: the effects of the disc and ligamentum flavum / Eur Spine J 18:679~686
Yoshida M / 1992 / Hypertrophied ligamentum flavum in lumbar spinal canal stenosis: pathogenesis and morphologic and immunohistochemical observation / Spine (Phila Pa 1976) 17:1353~1360
Kosaka H / 2007 / Pathomechanism of loss of elasticity and hypertrophy of lumbar ligamentum flavum in elderly patients with lumbar spinal canal stenosis / Spine (Phila Pa 1976) 32:2805~2811
Zhong ZM / 2011 / Hypertrophy of ligamentum flavum in lumbar spine stenosis associated with the increased expression of connective tissue growth factor / J Orthop Res 29:1592~1597
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