지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
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- 1 - 25 (25page)
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Endometrial hyperplasia (EH) comprises a spectrum of changes in the endometrium ranging from a slightly disordered pattern that exaggerates the alterations seen in the late proliferative phase of the menstrual cycle to irregular, hyperchromatic lesions that are similar to endometrioid adenocarcinoma. Generally, EH is caused by continuous exposure of estrogen unopposed by progesterone, polycystic ovary syndrome, tamoxifen, or hormone replacement therapy. Since it can progress, or often occur coincidentally with endometrial carcinoma, EH is of clinical importance, and the reversion of hyperplasia to normal endometrium represents the key conservative treatment for prevention of the development of adenocarcinoma. Presently, cyclic progestin or hysterectomy constitutes the major treatment option for EH without or with atypia, respectively. However, clinical trials of hormonal therapies and definitive standard treatments remain to be established for the management of EH. Moreover, therapeutic options for EH patients who wish to preserve fertility are challenging and require nonsurgical management. Therefore, future studies should focus on evaluation of new treatment strategies and novel compounds that could simultaneously target pathways involved in the pathogenesis of estradiol-induced EH. Novel therapeutic agents precisely targeting the inhibition of estrogen receptor, growth factor receptors, and signal transduction pathways are likely to constitute an optimal approach for treatment of EH.
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참고문헌 (178)
참고문헌 신청
Jabbour HN / 2006 / Endocrine regulation of menstruation / Endocr Rev 27:17~46
Medh RD / 2000 / Hormonal regulation of physiological cell turnover and apoptosis / Cell Tissue Res 301:101~124
Horne FM / 2007 / Progesterone receptor modulators and the endometrium : changes and consequences / Hum Reprod Update 13:567~580
Kaaks R / 2002 / Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review / Cancer Epidemiol Biomarkers Prev 11:1531~1543
Horn LC / 2004 / Risk of progression in complex and atypical endometrial hyperplasia: clinicopathologic analysis in cases with and without progestogen treatment / Int J Gynecol Cancer 14:348~353
Medh RD / 2000 / Hormonal regulation of physiological cell turnover and apoptosis / Cell Tissue Res 301:101~124
Horne FM / 2007 / Progesterone receptor modulators and the endometrium : changes and consequences / Hum Reprod Update 13:567~580
Kaaks R / 2002 / Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review / Cancer Epidemiol Biomarkers Prev 11:1531~1543
Horn LC / 2004 / Risk of progression in complex and atypical endometrial hyperplasia: clinicopathologic analysis in cases with and without progestogen treatment / Int J Gynecol Cancer 14:348~353
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