A Multi-stage Carcinogenesis Model to Investigate Caloric Restriction as a Potential Tool for Post-irradiation Mitigation of Cancer Risk

Shusuke Tani; Benjamin John Blyth; Yi Shang; Takamitsu Morioka; Shizuko Kakinuma; Yoshiya Shimada

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저자정보: Shusuke Tani (Department of Radiation Effects Research National Institute of Radiological Sciences Chiba Japan) Benjamin John Blyth (Department of Radiation Effects Research National Institute of Radiological Sciences Chiba Japan) Yi Shang (Department of Radiation Effects Research National Institute of Radiological Sciences Chiba Japan) Takamitsu Morioka (Department of Radiation Effects Research National Institute of Radiological Sciences Chiba Japan) Shizuko Kakinuma (Department of Radiation Effects Research National Institute of Radiological Sciences Chiba Japan) Yoshiya Shimada (Department of Radiation Effects Research National Institute of Radiological Sciences Chiba Japan)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제21권 제2호

발행연도: 2016.1

수록면: 115 - 120 (6page)

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The risk of radiation-induced cancer adds to anxiety in low-dose exposed populations. Safe and effective lifestyle changes which can help mitigate excess cancer risk might provide exposed individuals the opportunity to pro-actively reduce their cancer risk, and improve mental health and well-being. Here, we applied a mathematical multi-stage carcinogenesis model to the mouse lifespan data using adult-onset caloric restriction following irradiation in early life. We re-evaluated autopsy records with a veterinary pathologist to determine which tumors were the probable causes of death in order to calculate age-specific mortality. The model revealed that in both irradiated and unirradiated mice, caloric restriction reduced the age-specific mortality of all solid tumors and hepatocellular carcinomas across most of the lifespan, with the mortality rate dependent more on age owing to an increase in the number of predicted rate-limiting steps. Conversely, irradiation did not significantly alter the number of steps, but did increase the overall transition rate between the steps. We show that the extent of the protective effect of caloric restriction is independent of the induction of cancer from radiation exposure, and discuss future avenues of research to explore the utility of caloric restriction as an example of a potential post-irradiation mitigation strategy. (J Cancer Prev 2016;21:115-120)

참고문헌 (21)

참고문헌 신청

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이 논문의 저자 정보

Shusuke Tani

소속기관 Department of Radiation Effects Research National Institute of Radiological Sciences Chiba Japan