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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Cancer invasion is a critical factor for survival and prognosis of patients with cancer. Identifying and targeting factors thatinfluence cancer invasion are an important strategy to overcome cancer. In this study, we investigated the role of fascin known to beassociated with cancer invasion. Methods: Fascin depletion was performed with lentiviral short hairpin RNA against fascin mRNA and stable cell line (Fascindep) wasestablished. Matrigel-Transwell invasion and three-dimensional (3D) culture system were used to observe fascin depletion effects. In orderto observe the changes of protease secretion by fascin depleted cancer cells, protease antibody array was performed. Results: Fascin was highly expressed in invasive cancer cells. Fascin-depleted cells showed decreased cancer invasion in Matrigel-Transwellinvasion and 3D culture system. In addition, inhibition of proteases secreation and decrease of intracellular proteases mRNA expressionwere observed in fascin deplete cells. Conclusions: These results indicates that fascin is closely involved in proteases activity and cancer invasion. Therefore, fascin is a strategicallyimportant factor for controlling cancer invasion.
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