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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 95 - 102 (8page)
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초록· 키워드
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Allergy is nearly always triggered by protein molecules and the majority of individuals with documented immunologic reaction to foods or plants IgE reactions. However, proteins derived from herbal medicine act as an allergen is unknown. In this study, we aimed to confirm if herbal medicine, Astragalus membranaceus, at proteomic level may contain to trigger the immunoreactivity of IgE. If it does, what components of protein molecules in herbal medicine, Astragalus membranaceus, is react to a binding IgE. In order to resolve this hypothesis, we performed proteomic tools, SDS-PAGE stained coomassie blue and identified protein by LC-MS/MS. Also, we tested plasma IgE reactivity on an isolated protein of Astragalus membranaceus using western blot of human IgE and enzyme immunoassay panel, Allergy-Q test in 400 patients. Through the described performances, we could select four sera of positive candidate and identify Astragalus membranaceus IgE binding proteins. Our data suggested that herbal medicine, Astragalus membranaceus was possible to act an allergen by identify IgE binding protein with isolated protein of Astragalus membranaceus.
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등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Carlini, C.R. / 2002 / Plant toxic proteins with insecticidal properties. A review on their potentialities as bioinsecticides / Toxicon 40:1515~1539
Hoffmann-Sommergruber, K. / 2000 / Plant allergens and pathogenesis-related proteins. What do they have in common? / Int. Arch. Allergy Immunol 122:155~166
Fahlbusch, B. / 1998 / Further characterization of IgEbinding antigens in kiwi, with particular emphasis on glycoprotein allergens / J. Investig. Allergol. Clin. Immunol 8:325~332
Johansson, S.G. / 2004 / Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003 / J. Allergy Clin. Immunol 113:832~836
Sutton, B.J. / 1993 / The human IgE network / Nature 366:421~428
Hoffmann-Sommergruber, K. / 2000 / Plant allergens and pathogenesis-related proteins. What do they have in common? / Int. Arch. Allergy Immunol 122:155~166
Fahlbusch, B. / 1998 / Further characterization of IgEbinding antigens in kiwi, with particular emphasis on glycoprotein allergens / J. Investig. Allergol. Clin. Immunol 8:325~332
Johansson, S.G. / 2004 / Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003 / J. Allergy Clin. Immunol 113:832~836
Sutton, B.J. / 1993 / The human IgE network / Nature 366:421~428
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