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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 76 - 88 (13page)
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In this paper, we describe the development of a microfluidic cartridge and its controlling device for fully automated nucleic acid purification from fecal samples. All steps of the standard complicated process, including fecal sample pretreatment, lysis, washing, and elution, were integrated into a microfluidic cartridge that could be operated with minimal hands-on time requirement. The performance of the microfluidic cartridge was evaluated using fecal samples spiked with bacteria or virus as well as fecal microbiome analysis. Microfluidic cartridge-based nucleic acid purification exhibited similar or even higher performance compared to commercialized products with respect to the concentration and purity of bacterial DNA or viral RNA. It also showed a similar or higher detection capacity for microbiome diversity in clinical fecal samples, as well as similar or higher extraction efficiency from such samples. The development of microfluidic cartridgebased fully automated platform for nucleic acid purification from fecal samples may be an important milestone towards developing a point-of-care test for rapid and simple diagnosis of gastroenteritis and gut microbiome analysis.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Tam, C.C. / 2012 / Changes in causes of acute gastroenteritis in the United Kingdom over 15 years: microbiologic findings from 2 prospective, population-based studies of infectious intestinal disease / Clin. Infect. Dis. 54:1275~1286
Boschi-Pinto, C. / 2008 / Estimating child mortality due to diarrhoea in developing countries / B. World. Health. Organ. 86:710~717
Jamison, D.T. / 2006 / Disease Control Priorities in Developing Countries / Oxford Univ. Press and the World Bank :1~27
Fletcher, S. M. / 2013 / Prevalence of Gastrointestinal Pathogens In Developed and Developing Countries: Systematic Review and Meta-Analysis / J. Public Health Res 2:42~53
Sydnor, E. R. M. / 2011 / Hospital epidemiology and infection control in acute-care settings / Clin. Microbiol. Rev. 24:141~173
Boschi-Pinto, C. / 2008 / Estimating child mortality due to diarrhoea in developing countries / B. World. Health. Organ. 86:710~717
Jamison, D.T. / 2006 / Disease Control Priorities in Developing Countries / Oxford Univ. Press and the World Bank :1~27
Fletcher, S. M. / 2013 / Prevalence of Gastrointestinal Pathogens In Developed and Developing Countries: Systematic Review and Meta-Analysis / J. Public Health Res 2:42~53
Sydnor, E. R. M. / 2011 / Hospital epidemiology and infection control in acute-care settings / Clin. Microbiol. Rev. 24:141~173
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