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자료유형
학술저널
저자정보
Cheng-Chun Ji (Coloproctology Center Takano Hospital Kumamoto Japan) Shota Takano (Coloproctology Center Takano Hospital Kumamoto Japan)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.15 No.2
발행연도
2017.1
수록면
182 - 186 (5page)

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Background/Aims: Infliximab has proven to be effective in the treatment of perianal fistulas in Crohn’s disease (CD) but theefficacy of adalimumab is still unclear. The aim of this study is to assess the clinical efficacy of adalimumab and compare theresults with those for infliximab. Methods: Forty-seven CD patients treated for perianal fistulas with infliximab from September2005 to December 2010 (n=31), or with adalimumab from November 2010 to May 2012 (n=16), were enrolled in this retrospectivestudy. The following patient characteristics were analyzed; intestinal lesion site, fistula classification, seton placement,index of inflammatory bowel disease, C-reactive protein level, follow-up period, and the cumulative rate of nonrecurrence oraggravation of fistula. Results: There were no significant differences in the intestinal lesion site, fistula classification, inflammatorybowel disease index, C-reactive protein level, and the frequency of injection between the infliximab group and the adalimumabgroup. The cumulative rate of nonrecurrence or aggravation of fistula was 62.5% in the adalimumab group and 83.9% inthe infliximab group at 24 months after treatment (P =0.09). The risk factors for recurrence or aggravation may be related to setonplacement (P =0.02), gender (P =0.06), and fistula classification (P =0.07). Conclusions: There was no significant differencein the clinical efficacy of adalimumab and infliximab in the treatment of perianal fistulas in CD. However, fistula classificationmay be an important risk factor for recurrence or aggravation. The preliminary findings in this study show that further researchis warranted.

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