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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 249 - 254 (6page)
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초록· 키워드
오류제보하기
Crohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) that presents with abdominal pain, weight loss, and diarrhea. Although the etiology has not been fully elucidated, both environmental and genetic causes are known to be involved. Inchronic inflammatory conditions such as IBD, B lymphocytes are chronically stimulated, and they induce monoclonal expansionof plasma cells, sometimes resulting in monoclonal gammopathy of undetermined significance. Immunomodulators thatare commonly used to control inflammation, such as tumor necrosis factor-α (TNF-α) blockers could increase the possibilityof hematologic malignancy. The pathogenesis of multiple myeloma in association with TNF-α inhibitor therapy is attributedto decreased apoptosis of plasma cell populations. Here, we describe a case of a 36-year-old male patient who was diagnosedwith immunoglobulin A subtype smoldering multiple myeloma during the treatment for CD with infliximab and adalimumab. We report this case along with a review of the literature on cases of multiple myeloma that occurred in conjunction with CD.
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참고문헌 (19)
참고문헌 신청
Reynolds GJ / 2007 / Review article: multiple myeloma and inflammatory bowel disease / Dig Dis Sci 52:2022~2028
Carter A / 1980 / The physiopathological significance of benign monoclonal gammopathy: a study of 64 cases / Br J Haematol 46:565~574
Greipp PR / 1995 / Pathogenetic relation between monoclonal gammopathies of undetermined significance and multiple myeloma / Stem Cells 13(Suppl 2):10~21
Bouhnik Y / 1996 / Long-term follow-up of patients with Crohn’s disease treated with azathioprine or 6-mercaptopurine / Lancet 347:215~219
Farrell RJ / 2000 / Increased incidence of non-Hodgkin’s lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low / Gut 47:514~519
Carter A / 1980 / The physiopathological significance of benign monoclonal gammopathy: a study of 64 cases / Br J Haematol 46:565~574
Greipp PR / 1995 / Pathogenetic relation between monoclonal gammopathies of undetermined significance and multiple myeloma / Stem Cells 13(Suppl 2):10~21
Bouhnik Y / 1996 / Long-term follow-up of patients with Crohn’s disease treated with azathioprine or 6-mercaptopurine / Lancet 347:215~219
Farrell RJ / 2000 / Increased incidence of non-Hodgkin’s lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low / Gut 47:514~519
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