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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 99 - 108 (10page)
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Background/Aims: Colorectal cancer (CRC) is now a major public health problem with heavy morbidity and mortality in rural Africans despite the lingering dietary fiber-rich foodstuffs consumption. Studies have shown that increased intake of dietaryfiber which contribute to low fecal pH and also influences the activity of intestinal microbiota, is associated with a lowered riskfor CRC. However, whether or not the apparent high dietary fiber consumption by Africans do not longer protects against CRCrisk is unknown. This study evaluated dietary fiber intake, fecal fiber components and pH levels in CRC patients. Methods:Thirty-five subjects (CRC=21, control=14), mean age 45 years were recruited for the study. A truncated food frequency questionnaire and modified Goering and Van Soest procedures were used. Results: We found that all subjects consumed variety ofdietary fiber-rich foodstuffs. There is slight preponderance in consumption of dietary fiber by the control group than the CRCpatients. We also found a significant difference in the mean fecal neutral detergent fiber, acid detergent fiber, hemicellulose, celluloseand lignin contents from the CRC patients compared to the controls (P <0.05). The CRC patients had significantly morefecal pH level than the matched apparently healthy controls (P =0.017). Conclusions: The identified differences in the fecal fiber components and stool pH levels between the 2 groups may relate to CRC incidence and mortality in rural Africans. There iscrucial need for more hypothesis-driven research with adequate funding on the cumulative preventive role of dietary fiber-richfoodstuffs against colorectal cancer in rural Africans “today.”
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참고문헌 (41)
참고문헌 신청
Siegel R / 2014 / Cancer statistics, 2014 / CA Cancer J Clin 64:9~29
Katsidzira L / 2017 / The shifting epidemiology of colorectal cancer in sub-Saharan Africa / Lancet Gastroenterol Hepatol 2:377~383
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136:E359~E386
Irabor DO / 2008 / Colorectal carcinoma in West Africans: some considerations on its relatively lower incidence compared to caucasians / Pak J Med Sci 24:331~335
O'Keefe SJ / 2015 / Fat, fibre and cancer risk in African Americans and rural Africans / Nat Commun 6:6342
Katsidzira L / 2017 / The shifting epidemiology of colorectal cancer in sub-Saharan Africa / Lancet Gastroenterol Hepatol 2:377~383
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136:E359~E386
Irabor DO / 2008 / Colorectal carcinoma in West Africans: some considerations on its relatively lower incidence compared to caucasians / Pak J Med Sci 24:331~335
O'Keefe SJ / 2015 / Fat, fibre and cancer risk in African Americans and rural Africans / Nat Commun 6:6342
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