지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 109 - 115 (7page)
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초록· 키워드
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Background/Aims: The incidence and severity of Clostridium difficile infection (CDI) have increased worldwide, resulting ina need for rapid and accurate diagnostic methods. Methods: A retrospective study was conducted to compare CDI diagnosismethods between January 2014 and December 2014. The stool samples, which were obtained in presumptive CDI patients,were compared for their diagnostic accuracy and rapidity, including real-time polymerase chain reaction (PCR) of toxin genes,C. difficile toxin assay, and culture for C. difficile . Results: A total of 207 cases from 116 patients were enrolled in this study and117 cases (56.5%) were diagnosed as having CDI. Among the 117 cases, the sensitivities of real-time PCR, C. difficile toxin assay,and culture for C. difficile were 87.2% (102 cases; 95% CI, 80.7%−92.8%), 48.7% (57 cases; 95% CI, 41.0%−59.8%), and 65.0% (76cases; 95% CI, 60.2%−78.5%), respectively (P <0.005). Notably, 34 cases (29.0%) were diagnosed with CDI by real-time PCR only. The time required to obtain results was 2.27 hours (136.62±82.51 minutes) for real-time PCR, 83.67 hours (5,020.66±3,816.38minutes) for toxin assay, and 105.79 hours (6,347.68±3,331.46 minutes) for culture (P <0.005), respectively. Conclusions: Weconfirmed that real-time PCR of toxin genes is the most effective diagnostic method for accurate and early diagnosis of CDI. Italso helps to diagnose hypervirulent CDI, such as ribotype 027 infection.
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참고문헌 (21)
참고문헌 신청
O'Connor JR / 2009 / Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain / Gastroenterology 136:1913~1924
Pepin J / 2004 / Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity / CMAJ 171:466~472
Ricciardi R / 2007 / Increasing prevalence and severity of Clostridium difficile colitis in hospitalized patients in the United States / Arch Surg 142:624~631
Kristin E. Burke / 2014 / Clostridium difficile Infection: A Worldwide Disease / Gut and Liver 8(1):1~6
Kim YS / 2013 / Incidence and clinical features of Clostridium difficile infection in Korea: a nationwide study / Epidemiol Infect 141:189~194
Pepin J / 2004 / Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity / CMAJ 171:466~472
Ricciardi R / 2007 / Increasing prevalence and severity of Clostridium difficile colitis in hospitalized patients in the United States / Arch Surg 142:624~631
Kristin E. Burke / 2014 / Clostridium difficile Infection: A Worldwide Disease / Gut and Liver 8(1):1~6
Kim YS / 2013 / Incidence and clinical features of Clostridium difficile infection in Korea: a nationwide study / Epidemiol Infect 141:189~194
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