Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer

Yuk Fai Lam; Wai Kay Seto; Teresa Tong; Ka Shing Cheung; Oswens Lo; Ivan FN Hung; Wai Lun Law; Wai K Leung

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자료유형: 학술저널

저자정보: Yuk Fai Lam (Queen Mary Hospital The University of Hong Kong) Wai Kay Seto (Queen Mary Hospital The University of Hong Kong) Teresa Tong (Queen Mary Hospital The University of Hong Kong) Ka Shing Cheung (Queen Mary Hospital The University of Hong Kong) Oswens Lo (Queen Mary Hospital The University of Hong Kong) Ivan FN Hung (Queen Mary Hospital The University of Hong Kong) Wai Lun Law (Queen Mary Hospital The University of Hong Kong) Wai K Leung (Queen Mary Hospital The University of Hong Kong)

저널정보: 대한장연구학회 Intestinal research Intestinal research Vol.16 No.4

발행연도: 2018.1

수록면: 619 - 627 (9page)

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Background/Aims: We determined the rates of metachronous colorectal neoplasm in colorectal cancer (CRC) patients after resection for right (R)-sided or left (L)-sided cancer. Methods: Consecutive CRC patients who had undergone surgical resection for curative intent in our hospital between 2001 and 2004 were identified. R-sided colonic cancers refer to cancer proximal to splenic flexure whereas L-sided cancers include rectal cancers. Patients were included only if they had a clearing colonoscopy performed either before or within 6 months after the operation. Findings of surveillance colonoscopy performed up to 5 years after colonic resection were included in the analysis. Results: Eight hundred and sixty-three CRC patients underwent curative surgical resection during the study period. Three hundred and twenty-seven patients (107 R-sided and 220 L-sided) fulfilled the inclusion criteria and had at least 1 postoperative surveillance colonoscopy performed. The proportion of patients who had polyp and adenoma on surveillance colonoscopy was significantly higher among patients with L-sided than R-sided cancers (polyps: 30.9% vs. 19.6%, P=0.03; adenomas: 25.5% vs. 13.1%, P=0.01). The mean number of adenoma per patient on surveillance colonoscopy was also higher for patients with L-sided than R-sided tumors (0.52; 95% confidence interval [CI], 0.37–0.68 vs. 0.22; 95% CI, 0.08–0.35; P<0.01). Multivariate analysis showed that L-sided cancers, age, male gender and longer follow-up were independent predictors of adenoma detection on surveillance colonoscopy. Conclusions: Patients with L-sided cancer had a higher rate of metachronous polyps and adenoma than those with R-sided cancer on surveillance colonoscopy. (Intest Res 2018;16:619-627)

참고문헌 (2)

참고문헌 신청

Labianca R / 2010 / Primary colon cancer: ESMO clinical practice guidelines for diagnosis, adjuvant treatment and follow-up / Ann Oncol 21(Suppl 5):v70~v77

Glimelius B / 2010 / Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up / Ann Oncol 21(Suppl 5):v82~v86

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