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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Osteoclasts are multinucleated cells of hematopoietic origin that are responsible forthe degradation of old bone matrix. Osteoclast differentiation and activity are controlledby two essential cytokines, macrophage colony-stimulating factor (M-CSF) andthe receptor activator of nuclear factor-B ligand (RANKL). M-CSF and RANKL bindto their respective receptors c-Fms and RANK to stimulate osteoclast differentiationthrough regulation of delicate signaling systems. Here, we summarize the critical oressential signaling pathways for osteoclast differentiation including M-CSF-c-Fms signaling,RANKL-RANK signaling, and costimulatory signaling for RANK.
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참고문헌 (66)
참고문헌 신청
Takayanagi H / 2007 / Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems / Nat Rev Immunol 7:292~304
Seeman E / 2006 / Bone quality--the material and structural basis of bone strength and fragility / N Engl J Med 354:2250~2261
Teitelbaum SL / 2003 / Genetic regulation of osteoclast development and function / Nat Rev Genet 4:638~649
Sherr CJ / 1990 / Colony-stimulating factor-1 receptor / Blood 75:1~12
Suda T / 1999 / Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families / Endocr Rev 20:345~357
Seeman E / 2006 / Bone quality--the material and structural basis of bone strength and fragility / N Engl J Med 354:2250~2261
Teitelbaum SL / 2003 / Genetic regulation of osteoclast development and function / Nat Rev Genet 4:638~649
Sherr CJ / 1990 / Colony-stimulating factor-1 receptor / Blood 75:1~12
Suda T / 1999 / Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families / Endocr Rev 20:345~357
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