지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The standard treatment for epithelial ovarian cancer is maximal cytoreductive surgery and adjuvant chemotherapy. Neoadjuvant chemotherapy can be considered as an alternative treatment strategy when unacceptable primary surgery, in terms of gross residual tumor remaining at the end of cytoreduction, is expected or in cases where poor general condition renders extensive cytoreductive surgery unsuitable. Intraperitoneal chemotherapy is ideal for epithelial ovarian cancer because its spread is mainly limited to the peritoneal cavity. Several randomized controlled trials have reported a survival gain with intraperitoneal chemotherapy. However, disadvantages such as port-related complications, abdominal pain, and neurotoxicity hinder its wide use. Hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery has been suggested as an alternative treatment strategy for intraperitoneal chemotherapy. Ongoing clinical trials of hyperthermic intraperitoneal chemotherapy will quantify clinical outcomes in the future, such as the survival benefit in epithelial ovarian cancer.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Trimbos B / 2010 / Surgical staging and treatment of early ovarian cancer: long-term analysis from a randomized trial / J Natl Cancer Inst 102:982~987
Kehoe S / 2015 / Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial / Lancet 386:249~257
Vergote I / 2010 / Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer / N Engl J Med 363:943~953
Lim MC / 2010 / Residual cancer stem cells after interval cytoreductive surgery following neoadjuvant chemotherapy could result in poor treatment out-comes for ovarian cancer / Onkologie 33:324~330
Chi DS / 2012 / An analysis of patients with bulky advanced stage ovarian, tubal, and peritoneal carcinoma treated with primary debul-king surgery (PDS) during an identical time period as the randomized EORTC-NCIC trial of PDS vs neoadjuvant che-motherapy (NACT) / Gynecol Oncol 124:10~14
Kehoe S / 2015 / Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial / Lancet 386:249~257
Vergote I / 2010 / Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer / N Engl J Med 363:943~953
Lim MC / 2010 / Residual cancer stem cells after interval cytoreductive surgery following neoadjuvant chemotherapy could result in poor treatment out-comes for ovarian cancer / Onkologie 33:324~330
Chi DS / 2012 / An analysis of patients with bulky advanced stage ovarian, tubal, and peritoneal carcinoma treated with primary debul-king surgery (PDS) during an identical time period as the randomized EORTC-NCIC trial of PDS vs neoadjuvant che-motherapy (NACT) / Gynecol Oncol 124:10~14
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