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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 493 - 502 (10page)
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BACKGROUND: The interplay between neurogenesis and angiogenesis is crucial during the development mediated by neuro-angiogenic morphogens. In particular, the angiogenic activity of neuropeptides and their role in tissue regeneration have long been investigated for better understanding of their biological mechanisms and further applications. However, there have been few studies for direct comparison of angiogenic activities of neuropeptides for in vitro and in vivo models. In this study, we report that direct comparison of the angiogenic activities of neuropeptide Y, secretoneurin, and substance P (SP) immobilized on hydrogels in in vitro and in vivo experiments. METHODS: A hyaluronic acid-based hydrogel is prepared by utilizing acrylated hyaluronic acid and thiolated peptides as a crosslinker and angiogenic factors, respectively. Angiogenic activities of three neuropeptides are evaluated not only by in vitro angiogenic and gene expression assays, but also by an in vivo chronic myocardial infarction model. RESULTS: The comparison of in vitro angiogenic activities of three peptides demonstrates that the SP-immobilized hydrogel shows a higher degree of cell network formation and angiogenic-specific genes than those of the other peptides and the control case. In addition, a three-dimensional angiogenic assay illustrates that more sprouting is observable in the SP group. Evaluation of regenerative activity in the chronic myocardial infarction model reveals that all three peptideimmobilized hydrogels induce increased cardiac function as well as structural regeneration. Among all the cases, the SP group provided the highest regenerative activity both in vitro and in vivo. CONCLUSION: In our comparison study, the SP-immobilized hydrogel shows the highest angiogenic activity and tissue regeneration among the test groups. This result suggests that nerve regeneration factors help angiogenesis in damaged tissues, which also highlights the importance of the neuro-angiogenic peptides as an element of tissue regeneration.
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참고문헌 (34)
참고문헌 신청
Rouwkema J / 2016 / Vascularization and angiogenesis in tissue engineering: beyond creating static networks / Trends Biotechnol 34:733~745
Zachary I / 2011 / Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects / Heart 97:181~189
Goncalves LM / 2000 / Angiogenic growth factors: potential new treatment for acute myocardial infarction / Cardiovasc Res 45:294~302
Testa U / 2008 / Vascular endothelial growth factors in cardiovascular medicine / J Cardiovasc Med 9:1190~1221
Jain M / 2011 / Effect of hyperglycemia and neuropeptides on interleukin-8 expression and angiogenesis in dermal microvascular endothelial cells / J Vasc Surg 53:1654~1660
Zachary I / 2011 / Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects / Heart 97:181~189
Goncalves LM / 2000 / Angiogenic growth factors: potential new treatment for acute myocardial infarction / Cardiovasc Res 45:294~302
Testa U / 2008 / Vascular endothelial growth factors in cardiovascular medicine / J Cardiovasc Med 9:1190~1221
Jain M / 2011 / Effect of hyperglycemia and neuropeptides on interleukin-8 expression and angiogenesis in dermal microvascular endothelial cells / J Vasc Surg 53:1654~1660
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