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논문 기본 정보

자료유형
학술저널
저자정보
Jie Zhang (Mudanjiang Medical University) Hong Feng Liu (Mudanjiang Medical University China) 이봉효 (대구한의대학교) 장은영 (대구한의대학교) 이철원 (대구한의대학교) 조일제 (대구한의대학교) 안원근 (부산대학교) 양재하 (대구한의대학교) 김영우 (대구한의대학교) Rong Jie Zhao (Mudanjiang Medical University) Yi Yan Wu (Mudanjiang Medical University)
저널정보
대한약침학회 Journal of Acupuncture & Meridian Studies Journal of Acupuncture & Meridian Studies Vol.9 No.1
발행연도
2016.1
수록면
4 - 10 (7page)

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A previous study demonstrated that acupuncture at ST36 (Zu-San-Li) attenuates ethanol withdrawal (EW)-induced hyperactivation of the hypothalamic–pituitary–adrenal axis in rats. The current study investigated the involvement of hypothalamic norepinephrine (NE) in that process. Rats were intraperitoneally treated with 3 g/kg/d of ethanol or saline for 28 days. After 24 hours of EW, acupuncture was applied to rats at bilateral ST36 points or at nonacupoints (tail) for 1 minute. A high-performance liquid chromatography analysis showed that EW significantly increased both the NE and the 3-methoxy-4-hydroxy-phenylglycol (MHPG) levels in the hypothalamic paraventricular nucleus (PVN). Western blot analysis also revealed that EW markedly elevated the phosphorylation rates of tyrosine hydroxylase (TH), but spared TH protein expression in the PVN. However, acupuncture at ST36, but not at nonacupoints, greatly inhibited the increase in the hypothalamic NE, MHPG, and phosphorylation rates of TH. Additionally, postacupuncture infusion of NE into the PVN significantly attenuated the inhibitory effects of acupuncture at ST36 on the oversecretion of plasma corticosterone during EW. These results suggest that acupuncture at ST36 inhibits EW-induced hyperactivation of the hypothalamic NEergic system to produce therapeutic effects on the hypothalamic–pituitary–adrenal axis.

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