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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 276 - 290 (15page)
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The defective satiation signaling may contribute to the etiology of obesity. We investigated how dietary modification during maternal (pregnancy and lactation) and post-weaning affects obesity, insulin resistance (IR) and hypothalamic appetite responses in offspring in adulthood. Pregnant female SD rats were randomly allocated to either maternal high-fat diet (43% energy from fat) or control diet (12% energy from fat) until the end of suckling. After weaning for additional 4 weeks, half of the offsprings were continuously fed the same diet as the dam (C-C and H-H groups); the remainder received the counterpart diet (C-H and H-C groups). The long-term high-fat diet during maternal and post-weaning period (H-H group) led to susceptibility to obesity and IR through the significant increases of hypothalamic orexigenic genes compared to the maternal and post-weaning control diet group (C-C group). In contrast, the hypothalamic expression levels of anorexigenic genes, apolipoprotein E, leptin receptor, and activated signal transducer and activator of transcription protein 3 were significantly lower in H-H group with elevations in circulating insulin and leptin and body fat mass. However, dietary changes after weaning (H-C and C-H groups) partially modified these conditions. These results suggest that maternal and post-weaning diet conditions can potentially disrupt hypothalamic neuronal signal irrelevantly, which is essential for leptin's regulation of energy homeostasis and induce the risk of offspring to future metabolic disorders.
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참고문헌 (29)
참고문헌 신청
Taylor PD / 2007 / Developmental programming of obesity in mammals / Exp Physiol 92:287~298
Sullivan EL / 2014 / Maternal high fat diet consumption during the perinatal period programs offspring behavior / Physiol Behav 123:236~242
McMillen IC / 2006 / Regulation of leptin synthesis and secretion before birth: implications for the early programming of adult obesity / Reproduction 131:415~427
Gorski JN / 2006 / Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance / Am J Physiol Regul Integr Comp Physiol 291:R768~R778
Ikenasio-Thorpe BA / 2007 / Prenatal influences on susceptibility to diet-induced obesity are mediated by altered neuroendocrine gene expression / J Endocrinol 193:31~37
Sullivan EL / 2014 / Maternal high fat diet consumption during the perinatal period programs offspring behavior / Physiol Behav 123:236~242
McMillen IC / 2006 / Regulation of leptin synthesis and secretion before birth: implications for the early programming of adult obesity / Reproduction 131:415~427
Gorski JN / 2006 / Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance / Am J Physiol Regul Integr Comp Physiol 291:R768~R778
Ikenasio-Thorpe BA / 2007 / Prenatal influences on susceptibility to diet-induced obesity are mediated by altered neuroendocrine gene expression / J Endocrinol 193:31~37
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