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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 1 - 14 (14page)
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초록· 키워드
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Over two hundred twenty-eight million cases of coronavirus disease 2019 (COVID-19) in the world have been reported until the 21<SUP>st</SUP> of September 2021 after the first rise in December 2019. The virus caused the disease called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 4 million deaths blame COVID-19 during the last one year and 8 months in the world. Currently, four SARS-CoV-2 variants of concern are mainly focused by pandemic studies with limited experiments to translate the infectivity and pathogenicity of each variant. The SARS-CoV-2 α, β, γ, and δ variant of concern was originated from United Kingdom, South Africa, Brazil/Japan, and India, respectively. The classification of SARS-CoV-2 variant is based on the mutation in spike (S) gene on the envelop of SARS-CoV-2. This review describes four SARS-CoV-2 α, β, γ, and δ variants of concern including SARS-CoV-2 ε, ζ, η, ι, κ, and B.1.617.3 variants of interest and alert. Recently, SARS-CoV-2 δ variant prevails over different countries that have 3 unique mutation sites: E156del/R158G in the N-terminal domain and T478K in a crucial receptor binding domain. A particular mutation in the functional domain of the S gene is probably associated with the infectivity and pathogenesis of the SARS-CoV-2 variant.
목차
ABSTRACT
INTRODUCTION
SARS-CoV-2 α (B.1.1.7) VARIANT
SARS-CoV-2 β (B.1.351) VARIANT
SARS-CoV-2 γ (P.1) VARIANT
SARS-CoV-2 δ (B.1.617.2) VARIANT
SARS-CoV-2 ε, ζ, η, ι, κ, AND B.1.617.3 VARIANT OF INTEREST AND ALERT
SUSCEPTIBILITY OF SARS-CoV-2 VARIANTS TO MONOCLONAL Ab TREATMENT
DELTA VARIANT SURGES WORLDWIDE
A UNIQUE MUTATION SITE FOR DELTA VARIANT: T478K
CONCLUSION
REFERENCES
참고문헌 (63)
참고문헌 신청
Brown CM / 2021 / Outbreak of SARS-CoV-2 infections, including COVID-19 vaccine breakthrough infections, associated with large public gatherings-Barnstable County, Massachusetts, July 2021 / MMWR Morb Mortal Wkly Rep 70:1059~1062
Dagpunar J / 2021 / Interim estimates of increased transmissibility, growth rate, and reproduction number of the COVID-19 B.1.617.2 variant of concern in the United Kingdom / medRxiv, doi:10.1101/2021.06.03.21258293
Liu Y / 2021 / The reproductive number of the delta variant of SARS-CoV-2 is far higher compared to the ancestral SARS-CoV-2 virus / J Travel Med :taab124
Li B / 2021 / Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 delta variant / medRxiv. doi:10.1101/2021.07.07.21260122
Ong SWX / 2021 / Clinical and virological features of SARS-CoV-2 variants of concern: a retrospective cohort study comparing B.1.1.7(alpha), B.1.315 (beta), and B.1.617.2 (delta) / Clin Infect Dis :ciab721
Dagpunar J / 2021 / Interim estimates of increased transmissibility, growth rate, and reproduction number of the COVID-19 B.1.617.2 variant of concern in the United Kingdom / medRxiv, doi:10.1101/2021.06.03.21258293
Liu Y / 2021 / The reproductive number of the delta variant of SARS-CoV-2 is far higher compared to the ancestral SARS-CoV-2 virus / J Travel Med :taab124
Li B / 2021 / Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 delta variant / medRxiv. doi:10.1101/2021.07.07.21260122
Ong SWX / 2021 / Clinical and virological features of SARS-CoV-2 variants of concern: a retrospective cohort study comparing B.1.1.7(alpha), B.1.315 (beta), and B.1.617.2 (delta) / Clin Infect Dis :ciab721
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UCI(KEPA) : I410-ECN-0101-2022-517-000121191