지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.6 No.1
- 발행연도
- 2014.1
- 수록면
- 13 - 21 (9page)
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초록· 키워드
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Chronic urticaria (CU) is a common allergic skin disease that requires long-term pharmacological treatment. Some patients with severe CU suffer a poor quality of life. Although the pathogenic mechanisms of CU are not clearly understood, several groups have suggested that genetic mechanisms are involved in various CU cohorts. To further understand the molecular genetic mechanisms of CU, we summarize recent genetic data in this review. Although a few HLA alleles were suggested to be candidate markers in different ethnic groups, further replication studies that apply the recent classification are needed. Genetic polymorphisms in histamine-related genes, including FcεRI and HNMT, were suggested to be involved in mast cell activation and histamine metabolism. Several genetic polymorphisms of leukotriene-related genes, such as ALOX5, LTC4S, and the PGE2 receptor gene PTGER4, were suggested to be involved in leukotriene overproduction, a pathogenic mechanism. Further investigations using candidate gene approaches and genome-wide association studies (GWAS) will provide new insights into the molecular genetic mechanisms of CU, which will provide new marker genes for differentiation of CU phenotypes and identification of potential therapeutic targets.
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참고문헌 (100)
참고문헌 신청
Maurer M / 2011 / Unmet clinical needs in chronic spontaneous urticaria. A GA(2)LEN task force report / Allergy 66:317~330
Greaves MW / 1995 / Chronic urticaria / N Engl J Med 332:1767~1772
Allen P. Kaplan / 2012 / Treatment of Chronic Spontaneous Urticaria / Allergy, Asthma & Immunology Research 4(6):326~331
Asero R / 2002 / Chronic idiopathic urticaria: a family study / Ann Allergy Asthma Immunol 89:195~196
Zuberbier T / 2009 / EAACI/GA(2)LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria / Allergy 64:1417~1426
Greaves MW / 1995 / Chronic urticaria / N Engl J Med 332:1767~1772
Allen P. Kaplan / 2012 / Treatment of Chronic Spontaneous Urticaria / Allergy, Asthma & Immunology Research 4(6):326~331
Asero R / 2002 / Chronic idiopathic urticaria: a family study / Ann Allergy Asthma Immunol 89:195~196
Zuberbier T / 2009 / EAACI/GA(2)LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria / Allergy 64:1417~1426
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