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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.7 No.1
- 발행연도
- 2015.1
- 수록면
- 60 - 68 (9page)
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Purpose: Soy-based formulas are widely used as dairy substitutes to treat milk allergy patients. However, reactions to soy have been reported in a small proportion of patients with IgE-mediated milk allergies. The aim of this work was to explore whether P34, a mayor soybean allergen, is involved in this cross-reactivity. Methods: In vitro recognition of P34 was evaluated by immunoblotting, competitive ELISA and basophil activation tests (BAT) using sera from allergic patients. In vivo cross-reactivity was examined using an IgE-mediated milk allergy mouse model. Results: P34 was recognized by IgE antibodies from the sera of milk allergic patients, casein-specific monoclonal antibodies, and sera from milk-allergic mice. Spleen cells from sensitized mice incubated with milk, soy or P34 secreted IL-5 and IL-13, while IFN-γ remained unchanged. In addition, the cutaneous test was positive with cow’s milk proteins (CMP) and P34 in the milk allergy mouse model. Moreover, milk-sensitized mice developed immediate symptoms following sublingual exposure to P34. Conclusions: Our results demonstrate that P34 shares epitopes with bovine casein, which is responsible for inducing hypersensitivity symptoms in milk allergic mice. This is the first report of the in vivo cross-allergenicity of P34.
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참고문헌 (39)
참고문헌 신청
Julie Wang / 2009 / Food allergy: recent advances in pathophysiology and treatment / Allergy, Asthma & Immunology Research 1(1):19~29
Lehrer SB / 2002 / Current understanding of food allergens / Ann N Y Acad Sci 964:69~85
Gu X / 2001 / Identification of IgE-binding proteins in soy lecithin / Int Arch Allergy Immunol 126:218~225
Gómez-Ollés S / 2007 / Assessment of soy aeroallergen levels in different work environments / Clin Exp Allergy 37:1863~1872
Codina R / 2002 / Identification of the soybean hull allergens involved in sensitization to soybean dust in a rural population from Argentina and N-terminal sequence of a major 50 KD allergen / Clin Exp Allergy 32:1059~1063
Lehrer SB / 2002 / Current understanding of food allergens / Ann N Y Acad Sci 964:69~85
Gu X / 2001 / Identification of IgE-binding proteins in soy lecithin / Int Arch Allergy Immunol 126:218~225
Gómez-Ollés S / 2007 / Assessment of soy aeroallergen levels in different work environments / Clin Exp Allergy 37:1863~1872
Codina R / 2002 / Identification of the soybean hull allergens involved in sensitization to soybean dust in a rural population from Argentina and N-terminal sequence of a major 50 KD allergen / Clin Exp Allergy 32:1059~1063
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