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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 301 - 307 (7page)
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초록· 키워드
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We conducted this study to evaluate the combined effect of acellular bladder submucosamatrix (BSM) and autologous urethral tissue for the treatment of long segment urethralstricture in a rabbit model. To prepare the BSM, porcine bladder submucosa was processed,decellularized, configured into a sheet-like shape, and sterilized. Twenty rabbits wererandomized to normal control, urethral stricture, urethroplasty using BSM only or BSM/autologous urethral tissue (n = 5 per group). Retrograde urethrography was performed at4, 8, and 12 weeks postoperatively, and the grafted specimens were harvested at week 12to evaluate urethral reconstruction through histopathologic and immunohistochemicalanalysis. The mean urethral width of the control, stricture, BSM, and BSM/autologousurethral tissue groups at week 12 was 10.3 ± 0.80, 3.8 ± 1.35, 8.8 ± 0.84, and9.1 ± 1.14 mm, respectively. The histopathologic study revealed that the BSM/autologousurethral tissue graft had a normal area of urethral lumen, compact muscular layers,complete epithelialization, and progressive infiltration by vessels in the regeneratedurethra. In contrast, the BSM grafts revealed keratinized epithelium, abundantcollagenized fibrous connective tissue, and were devoid of bundles of circular smoothmuscle. Nontransected ventral onlay-augmented urethroplasty using an acellular BSMscaffold combined with an autologous urethral tissue graft represents a feasible procedurefor urethral reconstruction.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Sievert KD / 2012 / Introducing a large animal model to create urethral stricture similar to human stricture disease : a comparative experimental microscopic study / J Urol 187:1101~1109
Fiala R / 2007 / Porcine small intestinal submucosa graft for repair of anterior urethral strictures / Eur Urol 51:1702~1708
Kropp BP / 1996 / Characterization of small intestinal submucosa regenerated canine detrusor: assessment of reinnervation, in vitro compliance and contractility / J Urol 156:599~607
Kropp BP / 1998 / Rabbit urethral regeneration using small intestinal submucosa onlay grafts / Urology 52:138~142
Badylak SF / 2005 / Esophageal reconstruction with ECM and muscle tissue in a dog model / J Surg Res 128:87~97
Fiala R / 2007 / Porcine small intestinal submucosa graft for repair of anterior urethral strictures / Eur Urol 51:1702~1708
Kropp BP / 1996 / Characterization of small intestinal submucosa regenerated canine detrusor: assessment of reinnervation, in vitro compliance and contractility / J Urol 156:599~607
Kropp BP / 1998 / Rabbit urethral regeneration using small intestinal submucosa onlay grafts / Urology 52:138~142
Badylak SF / 2005 / Esophageal reconstruction with ECM and muscle tissue in a dog model / J Surg Res 128:87~97
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