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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 598 - 605 (8page)
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Bacterial infection is an important cause of death in patients with liver cirrhosis. The aim of this study was to investigate the clinical characteristics and prognostic impact of bacterial infection in hospitalized patients with alcoholic liver disease (ALD). We retrospectively analyzed data from 409 patients consecutively admitted to a tertiary referral center with ALD diagnosis. Of a total of 544 admissions, 133 (24.4%) cases presented with bacterial infection, of which 116 were community-acquired whereas 17 were hospitalacquired.
The common types of infection were pneumonia (38%), biliary tract infection (17%), soft tissue infection (12%), and spontaneous bacterial peritonitis (9%). Diabetes, serum Na <135 mM/L, albumin <2.5 g/dL, C-reactive protein ≥20 mg/L, systemic inflammatory response syndrome (SIRS) positivity were independently associated with bacterial infection in patients with ALD. Overall 30-day and 90-day mortalities in patients with bacterial infection were significantly (P < 0.001) higher than those without infection (22.3% vs. 5.1% and 32.3% vs. 8.2%, respectively). Furthermore, bacterial infection (HR, 2.2; 95% CI, 1.049-4.579, P = 0.037), SIRS positivity (HR, 2.5; 95% CI, 1.240-4.861, P = 0.010), Maddrey’s discriminant function score ≥32 (HR, 2.3; 95% CI, 1.036-5.222, P = 0.041), and hemoglobin <12 g/dL (HR, 2.4; 95% CI, 1.081-5.450, P = 0.032) were independent predictors of short-term mortality. In conclusion, bacterial infection and SIRS positivity predicted short-term prognosis in hospitalized patients with ALD. A thorough evaluation at admission or on clinical deterioration is required to detect possible infection with prompt management.
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참고문헌 (22)
참고문헌 신청
Mandayam S / 2004 / Epidemiology of alcoholic liver disease / Semin Liver Dis 24:217~232
2013 / KASL clinical practice guidelines: management of alcoholic liver disease / Clin Mol Hepatol 19:216~254
Yim HJ / 2013 / Prognosis of patients with alcoholic liver disease in Korea:Comparisons of prognostic models by a national-wide survey / Hepatol Int 7:S44
Rao R / 2009 / Endotoxemia and gut barrier dysfunction in alcoholic liver disease / Hepatology 50:638~644
Bonnel AR / 2011 / Immune dysfunction and infections in patients with cirrhosis / Clin Gastroenterol Hepatol 9:727~738
2013 / KASL clinical practice guidelines: management of alcoholic liver disease / Clin Mol Hepatol 19:216~254
Yim HJ / 2013 / Prognosis of patients with alcoholic liver disease in Korea:Comparisons of prognostic models by a national-wide survey / Hepatol Int 7:S44
Rao R / 2009 / Endotoxemia and gut barrier dysfunction in alcoholic liver disease / Hepatology 50:638~644
Bonnel AR / 2011 / Immune dysfunction and infections in patients with cirrhosis / Clin Gastroenterol Hepatol 9:727~738
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