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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 606 - 611 (6page)
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초록· 키워드
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Mucosal-associated invariant T (MAIT) cells and natural killer T (NKT) cells are known to play crucial roles in a variety of diseases, including autoimmunity, infectious diseases, and cancers. However, little is known about the roles of these invariant T cells in acute cholecystitis. The purposes of this study were to examine the levels of MAIT cells and NKT cells in patients with acute cholecystitis and to investigate potential relationships between clinical parameters and these cell levels. Thirty patients with pathologically proven acute cholecystitis and 47 age- and sex-matched healthy controls were enrolled. Disease grades were classified according to the revised Tokyo guidelines (TG13) for the severity assessment for acute cholecystitis. Levels of MAIT and NKT cells in peripheral blood were measured by flow cytometry. Circulating MAIT and NKT cell numbers were significantly lower in acute cholecystitis patients than in healthy controls, and these deficiencies in MAIT cells and NKT cell numbers were associated with aging in acute cholecystitis patients. Notably, a reduction in NKT cell numbers was found to be associated with severe TG13 grade, death, and high blood urea nitrogen levels. The study shows numerical deficiencies of circulating MAIT and NKT cells and age-related decline of these invariant T cells. In addition, NKT cell deficiency was associated with acute cholecystitis severity and outcome. These findings provide an information regarding the monitoring of these changes in circulating MAIT and NKT cell numbers during the course of acute cholecystitis and predicting prognosis.
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참고문헌 (31)
참고문헌 신청
Kimura Y / 2013 / TG13 current terminology, etiology, and epidemiology of acute cholangitis and cholecystitis / J Hepatobiliary Pancreat Sci 20:8~23
Lee SW / 2009 / Impact of the Tokyo guidelines on the management of patients with acute calculous cholecystitis / J Gastroenterol Hepatol 24:1857~1861
Wang AJ / 2003 / Clinical predictors of severe gallbladder complications in acute acalculous cholecystitis / World J Gastroenterol 9:2821~2823
Bondarev VI / 1990 / Disorders of immunoreactivity in acute cholecystitis in middle-aged and elderly patients and their correction in preventing postoperative complications / Klin Khir :27~29
Lantz O / 1994 / An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8-T cells in mice and humans / J Exp Med 180:1097~1106
Lee SW / 2009 / Impact of the Tokyo guidelines on the management of patients with acute calculous cholecystitis / J Gastroenterol Hepatol 24:1857~1861
Wang AJ / 2003 / Clinical predictors of severe gallbladder complications in acute acalculous cholecystitis / World J Gastroenterol 9:2821~2823
Bondarev VI / 1990 / Disorders of immunoreactivity in acute cholecystitis in middle-aged and elderly patients and their correction in preventing postoperative complications / Klin Khir :27~29
Lantz O / 1994 / An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8-T cells in mice and humans / J Exp Med 180:1097~1106
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