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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,503 - 1,508 (6page)
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초록· 키워드
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Several factors can affect the perioperative immune function. We evaluated the effect of propofol and desflurane anesthesia on the surgery-induced immune perturbation in patients undergoing breast cancer surgery. The patients were randomly assigned to receive propofol (n = 20) or desflurane (n = 20) anesthesia. The total and differential white blood cell counts were determined with lymphocyte subpopulations before and 1 hr after anesthesia induction and at 24 hr postoperatively. Plasma concentrations of interleukin (IL)-2 and IL-4 were also measured. Both propofol and desflurane anesthesia preserved the IL-2/IL-4 and CD4+/CD8+ T cell ratio. Leukocytes were lower in the propofol group than in the desflurane group at 1 hr after induction (median [quartiles], 4.98 [3.87-6.31] vs. 5.84 [5.18-7.94] 103/μL) and 24 hr postoperatively (6.92 [5.54-6.86] vs. 7.62 [6.22-9.21] 103/μL). NK cells significantly decreased 1 hr after induction in the propofol group (0.41 [0.34-0.53] to 0.25 [0.21-0.33] 103/μL), but not in the desflurane group (0.33 [0.29-0.48] to 0.38 [0.30-0.56] 103/μL). Our findings indicate that both propofol and desflurane anesthesia for breast cancer surgery induce a favorable immune response in terms of preservation of IL-2/IL-4 and CD4+/CD8+ T cell ratio in the perioperative period. With respect to leukocytes and NK cells, desflurane anesthesia is associated with less adverse immune responses than propofol anesthesia during surgery for breast cancer. (Clinical trial registration at https://cris.nih.go.kr/cris number: KCT0000939)
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
Tavare AN / 2012 / Cancer recurrence after surgery : direct and indirect effects of anesthetic agents / Int J Cancer 130:1237~1250
Tracey KJ / 2009 / Reflex control of immunity / Nat Rev Immunol 9:418~428
Mansi JL / 1999 / Outcome of primary-breast-cancer patients with micrometastases : a long-term follow-up study / Lancet 354:197~202
Heaney A / 2012 / Can anaesthetic and analgesic techniques affect cancer recurrence or metastasis? / Br J Anaesth 109:i17~i28
Tavare AN / 2012 / Cancer recurrence after surgery : direct and indirect effects of anesthetic agents / Int J Cancer 130:1237~1250
Tracey KJ / 2009 / Reflex control of immunity / Nat Rev Immunol 9:418~428
Mansi JL / 1999 / Outcome of primary-breast-cancer patients with micrometastases : a long-term follow-up study / Lancet 354:197~202
Heaney A / 2012 / Can anaesthetic and analgesic techniques affect cancer recurrence or metastasis? / Br J Anaesth 109:i17~i28
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