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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 558 - 569 (12page)
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Background: Obesity is well-known as a risk factor for heart failure, including diastolic dysfunction. However, this mechanism in high-fat diet (HFD)-induced obese rats remain controversial. The purpose of this study was to investigate whether cardiac dysfunction develops when rats are fed with a HFD for 10 weeks; additionally, we sought to investigate the association between mitochondrial abnormalities, adenosine triphosphate (ATP) levels and cardiac dysfunction. Methods: We examined myocardia in Wistar rats after 10 weeks of HFD (45 kcal% fat, n=6) or standard diet (SD, n=6). Echocardiography, histomorphologic analysis, and electron microscopy were performed. The expression levels of mitochondrial oxidative phosphorylation (OXPHOS) subunit genes, peroxisome-proliferator-activated receptor γ co-activator-1α (PGC1α) and anti-oxidant enzymes were assessed. Markers of oxidative stress damage, mitochondrial DNA copy number and myocardial ATP level were also examined. Results: After 10 weeks, the body weight of the HFD group (349.6±22.7 g) was significantly higher than that of the SD group (286.8±14.9 g), and the perigonadal and epicardial fat weights of the HFD group were significantly higher than that of the SD group. Histomorphologic and electron microscopic images were similar between the two groups. However, in the myocardium of the HFD group, the expression levels of OXPHOS subunit NDUFB5 in complex I and PGC1α, and the mitochondrial DNA copy number were decreased and the oxidative stress damage marker 8-hydroxydeoxyguanosine was increased, accompanied by reduced ATP levels. Conclusion: Diastolic dysfunction was accompanied by the mitochondrial abnormality and reduced ATP levels in the myocardium of 10 weeks-HFD-induced rats.
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참고문헌 (38)
참고문헌 신청
Kenchaiah S / 2002 / Obesity and the risk of heart failure / N Engl J Med 347:305~313
Powell BD / 2006 / Association of obesity with left ventricular remodeling and diastolic dysfunction in patients without coronary artery disease / Am J Cardiol 98:116~120
Cote AT / 2013 / Childhood obesity and cardiovascular dysfunction / Am Coll Cardiol 62:1309~1319
Aurigemma GP / 2013 / Cardiac remodeling in obesity / Circ Cardiovasc Imaging 6:142~152
Levin BE / 1997 / Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats / Am J Physiol 273(2 Pt 2):R725~R730
Powell BD / 2006 / Association of obesity with left ventricular remodeling and diastolic dysfunction in patients without coronary artery disease / Am J Cardiol 98:116~120
Cote AT / 2013 / Childhood obesity and cardiovascular dysfunction / Am Coll Cardiol 62:1309~1319
Aurigemma GP / 2013 / Cardiac remodeling in obesity / Circ Cardiovasc Imaging 6:142~152
Levin BE / 1997 / Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats / Am J Physiol 273(2 Pt 2):R725~R730
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