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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 187 - 196 (10page)
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Purpose: Clinical studies have reported a correlation between pelvic ischemia and voiding dysfunction in elderly men. The aim of this study was to identify and compare prostate structural modifications in cultured cells and in a rabbit model after exposure to hypoxia, oxidative stress, and chronic ischemia.
Materials and Methods: Cultured human prostate smooth muscle cells (SMCs), epithelial cells (ECs), and stromal cells (SCs) were incubated under normoxia, hypoxia, and oxidative stress conditions by use of a computerized oxycycler system. We developed a rabbit model of chronic prostate ischemia by creating aorto-iliac arterial atherosclerosis. Markers of oxidative stress were examined by using fluorometric analysis and enzyme immunoassay. Prostate structure was examined by using Masson’s trichrome staining and transmission electron microscopy (TEM).
Results: Lipid peroxidation was found in SMCs exposed to hypoxia and in all cell types exposed to oxidative stress. We identified protein oxidation in ECs exposed to hypoxia and in all cell types exposed to oxidative stress. Markers indicating oxidative damage were present in chronically ischemic rabbit prostate tissue. These reactions were associated with DNA damage. Prostate ischemia resulted in epithelial atrophy, loss of smooth muscle, and diffuse fibrosis. TEM showed swollen mitochondria with degraded cristae, loss of membrane, loss of Golgi bodies, degenerated nerves, and disrupted cell-to-cell junctions.
Conclusions: Human prostate cells exhibited differential reactions to hypoxia and oxidative stress with widespread DNA damage. Structural modifications in ischemic prostate tissue were similar to those in cells exposed to oxidative stress. Structural changes due to ischemia and oxidative stress may contribute to prostatic noncompliance in aging men.
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참고문헌 (30)
참고문헌 신청
Berry SJ / 1984 / The development of human benign prostatic hyperplasia with age / J Urol 132:474~479
Jacobsen SJ / 2001 / Natural history of benign prostatic hyperplasia / Urology 58(6 Suppl 1):5~16
Madersbacher S / 1998 / The aging lower urinary tract: a comparative urodynamic study of men and women / Urology 51:206~212
Barry MJ / 1993 / Relationship of symptoms of prostatism to commonly used physiological and anatomical measures of the severity of benign prostatic hyperplasia / J Urol 150(2 Pt 1):351~358
Bosch JL / 1995 / Reasons for the weak correlation between prostate volume and urethral resistance parameters in patients with prostatism / J Urol 153(3 Pt 1):689~693
Jacobsen SJ / 2001 / Natural history of benign prostatic hyperplasia / Urology 58(6 Suppl 1):5~16
Madersbacher S / 1998 / The aging lower urinary tract: a comparative urodynamic study of men and women / Urology 51:206~212
Barry MJ / 1993 / Relationship of symptoms of prostatism to commonly used physiological and anatomical measures of the severity of benign prostatic hyperplasia / J Urol 150(2 Pt 1):351~358
Bosch JL / 1995 / Reasons for the weak correlation between prostate volume and urethral resistance parameters in patients with prostatism / J Urol 153(3 Pt 1):689~693
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